IP Library Granted Patent US 8,444,988
Granted Patent B2
US 8,444,988 · App. 13/294,496 · Granted May 21, 2013

Cancer treatment method

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Quick Facts
Patent No.
US 8,444,988
App. No.
13/294,496
Granted
May 21, 2013
Kind
B2
Abstract

A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as a pharmaceutical combination including the 4-quinazolineamines.

Claims (10)

1. A method of treating breast cancer in a mammal, comprising administering to said mammal a therapeutically effective amount of:

(a) the compound of formula II:

or a pharmaceutically acceptable salt thereof; and

(b) trastuzumab.

2. The method of claim 1 , wherein the mammal is human.

3. The method of claim 1 , wherein the pharmaceutically acceptable salt is ditosylate.

4. A method of treating breast cancer in a mammal, comprising administering to said mammal a therapeutically effective amount of:

(a)

ditosylate monohydrate; and

(b) trastuzumab.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2015
From: LEO OSPREY LIMITED
To: NOVARTIS AG
Reel/Frame 035771/0154 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2015
From: GLAXOSMITHKLINE LLC
To: LEO OSPREY LIMITED
Reel/Frame 035762/0741 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2014
From: LACKEY, KAREN ELIZABETH; MULLEN, ROBERT J.; SPECTOR, NEIL; WOOD, III, EDGAR RAYMOND; XIA, WENLE
To: GLAXOSMITHKLINE LLC
Reel/Frame 033209/0675 →