Treatment for obesity
View Patent ↗The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.
1. A 33 amino acid peptide, wherein the peptide is not eel or salmon calcitonin or human amylin, and wherein the thirty-one amino acids making up positions 2-33 of the peptide are identical to the thirty-one amino acids making up positions 1-32 of SEQ ID NO: 1.
2. The peptide of claim 1 , wherein position 1 of the peptide is lysine.
3. The peptide of claim 2 , wherein position 33 of the peptide is amidated.
4. The peptide of claim 3 , wherein position 27 of the peptide is Asp, position 28 of the peptide is Val, position 30 of the peptide is Ala, position 31 of the peptide is Asn, and position 33 of the peptide is Tyr.
5. A peptide whose amino acid sequence is at least 93 percent identical to SEQ ID NO: 1, wherein the peptide is not eel or salmon calcitonin or human amylin, wherein positions 2-30 of the peptide are identical to positions 2-30 of SEQ ID NO: 1, wherein position 26 of the peptide is Asp, wherein position 27 of the peptide is Val, wherein position 29 of the peptide is Ala, wherein position 30 of the peptide is Asn, and wherein position 1 of the peptide is cysteine that has been modified to reduce its positive charge.
6. The peptide of claim 5 , wherein position 32 of the peptide is amidated.
7. The peptide of claim 5 , wherein the cysteine has been modified with an acetyl group.
8. The peptide of claim 5 , wherein the cysteine has been modified with a succinyl group.
9. The peptide of claim 5 , wherein position 32 of the peptide is selected from one of proline or tyrosine.
10. A pharmaceutical composition comprising the peptide of claim 4 and a pharmaceutically acceptable excipient, diluent or carrier.
11. A pharmaceutical composition comprising the peptide of claim 6 and a pharmaceutically acceptable excipient, diluent or carrier.
12. A method of treating obesity comprising administering to a patient in need of such treatment an amount of the peptide of claim 10 effective to suppress appetite.
13. A method of treating obesity comprising administering to a patient in need of such treatment an amount of the peptide of claim 11 effective to suppress appetite.
14. A method of suppressing appetite comprising administering to a patient in need of such suppression or treatment an amount of the peptide of claim 4 effective to suppress appetite.
15. A method of suppressing appetite comprising administering to a patient in need of such suppression or treatment an amount of the peptide of claim 6 effective to suppress appetite.
16. A method of treating obesity comprising administering to a patient in need of such treatment an amount of the pharmaceutical composition of claim 10 effective to suppress appetite.
17. A method of suppressing appetite comprising administering to a patient in need of such suppression or treatment an amount of the pharmaceutical composition of claim 12 effective to suppress appetite.
18. A method of treating diabetes comprising administering to a patient in need of such treatment a therapeutically effective amount of the peptide of claim 4 .
19. A method of treating diabetes comprising administering to a patient in need of such treatment a therapeutically effective amount of the peptide of claim 6 .
20. A method of treating diabetes comprising administering to a patient in need of such treatment a therapeutically effective amount of the pharmaceutical composition of claim 10 .