Bone void fillers
A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.
1. A bone void filler composition comprising:
an acidic calcium phosphate component from about 8 wt % to about 12 wt % of the composition;
an osteoinductive demineralized bone component from about 70 wt % to about 80 wt % of the composition; and
an osteoconductive collagen carrier component from about 10 wt % to about 16 wt % of the composition;
wherein the composition is in the form of a porous three dimensional structure; and
wherein the composition has a pH from about 3 to about 5;
with the proviso that the acidic calcium phosphate component is not Ca 3 (PO 4 )2H 2 O.
2. The bone void filler composition of claim 1 , wherein the acidic calcium phosphate component comprises monocalcium phosphate monohydrate [Ca(H 2 PO 4 )2H 2 O]; calcium hydrogen phosphate dihydrate [CaHPO 4 2H 2 O], anhydrous calcium hydrogen phosphate [CaHPO 4 ], partially dehydrated calcium hydrogen phosphate [CaHPO 4 xH 2 O, where x is between 0 and 2], and/or calcium pyrophosphate (Ca 2 O 7 P 2 ) [2CaO 2 P 2 O 5 ].
3. The bone void filler composition of claim 2 , wherein the acidic calcium phosphate component comprises anhydrous calcium hydrogen phosphate [CaHPO 4 ], partially dehydrated calcium hydrogen phosphate [CaHPO 4 xH 2 O, where x is between 0 and 2], and/or calcium hydrogen phosphate dihydrate [CaHPO 4 2H 2 O].
4. The bone void filler composition of claim 1 , further comprising an additive selected from the group consisting of allograft chips, bioceramics, biocomposites, calcium salts other than the acidic calcium phosphate component, phosphate salts other than the acidic calcium phosphate component; and combinations thereof.
5. The bone void filler composition of claim 1 , further comprising an additive selected from the group consisting of bioresorbable fibers, synthetic polymers, and combinations thereof.
6. The bone void filler composition of claim 1 , wherein the demineralized bone is in a form selected from a powder, particle, granule, fiber, and combinations thereof.
7. The bone void filler composition of claim 6 , wherein the demineralized bone is in a form selected from a particle, granule, and combinations thereof.
8. The bone void filler composition of claim 7 , wherein the demineralized bone particle or granule size is from about 105 μm to about 850 μm.
9. The bone void filler composition of claim 1 , wherein the demineralized bone component is derived from a human donor.
10. The bone void filler composition of claim 1 , wherein the osteoconductive collagen carrier component comprises collagen from a non-human mammal.
11. The bone void filler composition of claim 10 , wherein the osteoconductive collagen carrier component comprises bovine collagen.
12. The bone void filler composition of claim 10 , wherein the osteoconductive collagen component comprises Type I and/or Type III collagen.
13. The bone void filler composition of claim 12 , wherein the osteoconductive collagen component comprises more than about 90 wt % Type I and less than about 10 wt % Type III collagen.
14. The bone void filler composition of claim 1 , further comprising a liquid carrier selected from selected from the group consisting of i) biological fluids selected from the group consisting of bone marrow aspirate, whole blood, serum, and/or plasma, ii) biocompatible liquids selected from the group consisting of water, saline and/or aqueous buffers, and iii) combinations of i) and ii).
15. The bone void filler composition of claim 14 , wherein the liquid carrier comprises bone marrow aspirate and saline.
16. The bone void filler composition of claim 1 , which is lyophilized.
17. The bone void filler composition of claim 1 , wherein the porous three dimensional structure is in the form of a strip, disc, sheet, bullet or cylinder.
18. The bone void filler composition of claim 1 , wherein the porous three dimensional structure is shaped for dental ridge augmentation.