Adhesive Laminates for Rapid Wound Occlusion
Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.
1 . A dispenser for an adhesive tape, comprising:
a biocompatible non-adherent substance;
a means to dispense an adhesive layer onto a layer of said biocompatible non-adherent substance;
a means to cut said combined layers; and
a housing having an opening.
2 . The dispenser of claim 1 , wherein said biocompatible non-adherent substance dissolves upon contact with a fluid.
3 . The dispenser of claim 1 , wherein one or more layers of said biocompatible non-adherent substance comprises a hydrocolloid.
4 . The dispenser of claim 1 , wherein the layer of said biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof.
5 . The dispenser of claim 1 , wherein said adhesive is cyanoacrylate or a derivative thereof, a protein or a synthetic polymer.
6 . The dispenser of claim 1 , wherein the means to dispense said adhesive comprises a brush impregnated with said adhesive.
7 . The dispenser of claim 1 , wherein the means to dispense said adhesive comprises:
a brush; and
an ampoule to contain said adhesive fluidly connected to said brush.
8 . A method of forming an adhesive tape to join one or more tissues, comprising:
withdrawing a length of the layer of said biocompatible non-adherent substance through the opening in the dispensor of claim 1 ;
simultaneously dispensing the adhesive layer along the length of the layer of said biocompatible non-adherent substance via the brush in said dispensor; and
cutting the combined layers via the cutting means comprising said dispenser after sufficient length has been withdrawn thereby forming said adhesive tape.
9 . The method of claim 8 , further comprising:
positioning said adhesive tape on one or more tissues, said adhesive layer in contact with said tissue(s); and
setting said adhesive thereby joining said tissue(s).