IP Library › Granted Patent US 9,260,523
Granted Patent B2
US 9,260,523 · App. 13/301,627 · Granted Feb 16, 2016

Methods and compositions for inhibiting CD32b expressing cells

Inventors: Seung Yup Chu (Cypress, CA); John R. Desjarlais (Pasadena, CA); Sher Bahadur Karki (Pomona, CA); Gregory Alan Lazar (Arcadia, CA); Gregory L. Moore (Monrovia, CA); Igor Vostiar (Monrovia, CA)
Assignee: Xencor, Inc.
C07K16/283C07K16/00C07K16/2803C07K16/2851C07K16/2878C07K2317/24C07K2317/52C07K2317/524C07K2317/53C07K2317/71C07K2317/72C07K2317/73C07K2317/732C07K2317/734C07K2317/77
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Quick Facts
Patent No.
US 9,260,523
App. No.
13/301,627
Granted
Feb 16, 2016
Kind
B2
Abstract

The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.

Claims (1)

1. A method of activating at least one B cell or dendritic cell comprising contacting the cell with an immunoglobulin comprising an Fc region that binds FcγRIIb on the cell surface with enhanced affinity as compared to a parent immunoglobulin and at least one Fv region that binds CD40 on the cell surface, wherein the immunoglobulin comprises Fc substitutions S267E and L328F as compared to a parent Fc region, wherein the numbering is according to the EU index, as in Kabat.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2011
From: CHU, SEUNG YUP; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; LAZAR, GREGORY ALAN; MOORE, GREGORY L.; VOSTIAR, IGOR
To: XENCOR, INC.
Reel/Frame 027350/0116 →
Continuity (13)
Continuation 12156183 · May 30, 2008
Provisional Application 60940776 · May 30, 2007
Provisional Application 60953174 · Jul 31, 2007
Provisional Application 60970413 · Sep 6, 2007
Provisional Application 60976279 · Sep 28, 2007
Provisional Application 60990509 · Nov 27, 2007
Provisional Application 61012035 · Dec 6, 2007
Provisional Application 61013775 · Dec 14, 2007
Provisional Application 61019395 · Jan 7, 2008
Provisional Application 61032059 · Feb 27, 2008
Provisional Application 61043585 · Apr 9, 2008
Provisional Application 61046397 · Apr 18, 2008
Related Publication 20120148578A1 · Jun 14, 2012