Anti-IL-6 antibodies for the treatment of anemia
View Patent ↗The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat anemia (e.g., anemia associated with chemotherapy) including persons on a treatment regimen with a drug or chemotherapy and/or radiation for cancer (e.g., head and neck cancer) that is associated with increased risk of anemia.
1. A cancer treatment regimen comprising treating a cancer patient with cisplatin, radiotherapy, and an anti-IL-6 antibody comprising a light chain polypeptide having the amino acid sequence of SEQ ID NO:702 and a heavy chain polypeptide having the amino acid sequence of SEQ ID NO:704, wherein the patient is treated with said anti-IL-6 antibody on week 0 and week 4, is treated with cisplatin on week 0 and week 3, and is administered radiotherapy 5 times weekly from week 0 until week 8, and wherein the treated patient does not exhibit a hemoglobin level below 8 g/dL at 8 weeks after the initiation of the treatment regimen.