Substituted purine and 7-deazapurine compounds
View Patent ↗The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
1. A compound selected from
and pharmaceutically acceptable salts thereof.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. A compound
4. A pharmaceutically acceptable salt of
5. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
6. A pharmaceutical composition comprising a compound of claim 4 and a pharmaceutically acceptable carrier.