Elongated expandable member for occluding varicose veins
View Patent ↗Assemblies, kits, and methods for occluding a vascular vessel, such as a varicose vein, are disclosed. An assembly can include a removable inner member, a removable outer member, and an elongated expandable member positioned in a compressed form between portions of the inner and outer members. To facilitate their removal, one or both of the inner and outer members can include a handle coupled to a proximal end. The elongated expandable member can include a gelatin material or a collagen material that is configured, when wetted, to expand from a compressed first diametrical size to a second larger diametrical size within a time period of 5 minutes or less. At the second larger diametrical size, the gelatin or collagen material can occlude a vascular vessel for a period of at least 20 days without degrading.
1. An assembly, comprising:
a removable inner member, the inner member including a handle coupled to a proximal end portion;
a removable outer member, the outer member including an impermeable material; and
an elongated expandable member, including a gelatin material or a collagen material having a degree of vapor cross-linking characterized by Lysine residuals of 1.5% or less, positioned in a compressed form between a longitudinal inner surface of the outer member and a longitudinal outer surface of the inner member,
the elongated expandable member longitudinally positionable in alignment within a portion of the natural flow duct of a vascular vessel and configured to expand and occlude the duct of the vascular vessel following in situ separation and removal of the outer member.
2. The assembly of claim 1 , wherein the degree of cross-linking is configured to prevent the gelatin or collagen material from degrading for a period of at least 20 days.
3. The assembly of claim 1 , wherein the elongated expandable member includes a density between 0.005 g/cm 3 and 0.010 g/cm 3 .
4. The assembly of claim 1 , wherein the elongated expandable member includes a wicking agent selected from a salt or a sugar.
5. The assembly of claim 1 , wherein the elongated expandable member is configured to expand, when wetted, from a compressed first diametrical size to a second larger diametrical size, the second larger diametrical size at least 5 times the first diametrical size.
6. The assembly of claim 5 , wherein the elongated expandable member includes a length of at least 10 centimeters, and wherein the elongated expandable member completely expands in situ from the first diametrical size to the second larger diametrical size within a time period of 5 minutes or less.
7. The assembly of any one of claim 5 or 6 , wherein the second larger diametrical size of the elongated expandable member is substantially equal to a pre-wetted size of the member before being compressed and positioned between the longitudinal inner surface of the outer member and the longitudinal outer surface of the inner member.
8. The assembly of claim 1 , wherein the elongated expandable member includes an antimicrobial agent selected from a silver compound, chlorhexidine, an antibiotic, or an iodine-containing agent.
9. The assembly of claim 1 , wherein the elongated expandable member includes a pH adjuster in a concentration that results in the member having a pH greater than 5.7, the pH adjuster selected from hydrochloric acid, sodium hydroxide, or a buffer.
10. The assembly of claim 1 , wherein the outer member includes a handle, configured to detachably couple to the handle of the inner member, at a proximal end portion.
11. The assembly of claim 1 , wherein the elongated expandable member includes a drug having a property of promoting tissue in-growth to accelerate vascular vessel closure.