Software-reconfigurable conduit and reaction chamber microfluidic arrangements for lab-on-a-chip and miniature chemical processing techologies
View Patent ↗Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.
1. An electrically controllable and reconfigurable multipurpose microfluidic embedded chemical processor system, the system comprising:
a plurality of electrically operated valves for controlling the flow of the chemical substances, wherein each of the electrically operated valves comprises a plurality of flow ports and a plurality of electrical connections, wherein at least one flow port of each of the electrically operated valve is connected to at least one microfluidic conduit selected from the first plurality of microfluidic conduits and at least one microfluidic conduit selected from the second plurality of microfluidic conduits;
an electrical power distribution system for providing electrical power to at least one of the electrically operated valves and one or more electrically operated reaction controlling elements;
a microfluidic chemical routing network comprising:
a plurality of chemical interface ports for the transport of chemical substances, wherein each of the chemical interface ports is connected to an associated microfluidic conduit of a first plurality of microfluidic conduits for the transport of chemical substances, wherein the first plurality of microfluidic conduits are fabricated at a micrometer-scale to millimeter-scale,
a second plurality of microfluidic conduits for the transport of the chemical substances, wherein the second plurality of microfluidic conduits further fabricated at a micrometer-scale to millimeter-scale;
a plurality of chemical reactor devices comprising chemical reactor chambers, each of the chemical reactor chambers comprising at least one associated electrically operated reaction controlling element to facilitate a chemical reaction, wherein each of the chemical reactor devices are connected to at least one microfluidic conduit selected from the second plurality of microfluidic conduits, and wherein at least one of the plurality of chemical reactors is connected to at least one of the chemical interface ports; and
at least one electronic processor of a control system configured to control at least one of the electrically operated valves with the microfluidic chemical routing network to control the flow of the chemical substances and interact with one or more electrically operated reaction controlling elements,
wherein the electronic processor is configured to control a first group of the valves according to a configuration manager algorithm comprising a control manager element and is further configured to control a second group of the valves according to a process control algorithm comprised by a process control element.
2. The system of claim 1 wherein at least one of the electrically operated reaction-controlling elements comprises a light source for use in controlling chemical reactions.
3. The system of claim 1 wherein at least one of the electrically operated reaction-controlling elements comprises an optical stimulator for use in controlling chemical reactions.
4. The system of claim 1 wherein at least one of the electrically operated reaction elements comprises an acoustic transducer.
5. The system of claim 1 wherein at least one of the electrically operated reaction elements comprises a sonic vibrator.
6. The system of claim 1 wherein at least one of the electrically operated reaction elements comprises a heater.
7. The system of claim 1 wherein at least one of the electrically operated reaction elements comprises a microfluidic mixer.
8. The system of claim 1 wherein at least one of the chemical reactor chambers comprises a sensor.
9. The system of claim 1 wherein at least one microfluidic conduit selected from the first and the second plurality of microfluidic conduits comprises a flow-rate sensor.
10. The system of claim 1 wherein at least one microfluidic conduit selected from the first and the second plurality of microfluidic conduits comprises a temperature sensor.
11. The system of claim 1 wherein at least one microfluidic conduit selected from the first and the second plurality of microfluidic conduits comprises an ion concentration sensor.
12. The system of claim 1 wherein at least one microfluidic conduit selected from the first and the second plurality of microfluidic conduits comprises a particulate turbidity sensor.
13. The system of claim 2 wherein at least one microfluidic conduit selected from the first and the second plurality of microfluidic conduits comprises an optical sensor.
14. The system of claim 2 wherein the electrically controllable microfluidic chemical routing network comprise means for clearing at least some portions of the first and second plurality of microfluidic conduits.
15. The system of claim 1 wherein the electrically controllable microfluidic chemical routing network comprise means for cleaning at least some portions of the first and second plurality of microfluidic conduits.
16. The system of claim 1 wherein the electrically controllable microfluidic chemical routing network: comprise means for drying at least some portions of the first and second plurality of microfluidic conduits.
17. The system of claim 1 wherein the microfluidic chemical routing network further comprises electronics for controlling at least one of the electrically operated valves.
18. The system of claim 1 wherein the microfluidic chemical routing network further comprises electronics for controlling at least one of the electrically operated reaction-controlling elements.
19. The system of claim 1 wherein the control system receives signals from at least one sensor.
20. The. system of claim 1 wherein the control system receives incoming control signals.
21. The system of claim 1 wherein the physical structure further comprises a control system for controlling at least one of the electrically operated reaction-controlling elements.
22. The system of claim 21 wherein the control system receives signals from at least one sensor.
23. The system of claim 21 wherein the control system receives incoming control signals.