Wound dressing materials
View Patent ↗A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.
1. A wound dressing material comprising:
a wound dressing carrier;
N-acetyl cysteine or a salt or derivative thereof; and
a stabilized ascorbate;
wherein the weight ratio of N-acetyl cysteine or a salt or derivative thereof to said stabilized ascorbate is from about 1:4 to about 4:1; and
wherein said stabilized ascorbate comprises ascorbate-2-triphosphate.
2. A wound dressing material according to claim 1 , wherein the material comprises from about 0.1 wt. % to about 20 wt. % of said N-acetyl cysteine or salts or derivatives thereof, and from about 0.1 wt. % to about 20 wt. % of said stabilized ascorbate.
3. A wound dressing material according to claim 2 , wherein the material comprises from about 1 wt. % to about 10 wt. % of said N-acetyl cysteine or salts or derivatives thereof, and from about 1 wt. % to about 10 wt. % of said stabilized ascorbate.
4. A wound dressing material according to claim 1 , wherein the material comprises N-acetyl cysteine and ascorbate-2-triphosphate.
5. A wound dressing material according to claim 1 , wherein the carrier comprises a woven or nonwoven fabric, a foam, a freeze-dried or solvent-dried sponge, or a solid film.
6. A wound dressing material according to claim 1 , wherein the wound dressing carrier is bioabsorbable.
7. A wound dressing material according to claim 1 , wherein the carrier comprises a freeze-dried or solvent-dried sponge, and said sponge carrier comprises oxidized cellulose, optionally in combination with collagen or chitosan.
8. A method for treatment of a chronic dermal wound, comprising:
providing a wound dressing wherein the wound dressing comprises a wound dressing carrier, and in the carrier a N-acetyl cysteine or a salt or derivative thereof and stabilized ascorbate; and
applying the wound dressing to the chronic dermal wound;
wherein the weight ratio of N-acetyl cysteine or a salt or derivative thereof to said stabilized ascorbate is from about 1:4 to about 4:1; and
wherein said stabilized ascorbate comprises ascorbate-2-triphosphate.
9. A wound dressing comprising a wound dressing material comprising:
a wound dressing carrier;
N-acetyl cysteine or a salt or derivative thereof; and
a stabilized ascorbate;
wherein the weight ratio of N-acetyl cysteine or a salt or derivative thereof to said stabilized ascorbate is from about 1:4 to about 4:1;
wherein said stabilized ascorbate comprises ascorbate-2-triphosphate.
10. A wound dressing according to claim 9 which is sterile and packaged in a microorganism-impermeable container.
11. A method of treatment of a wound comprising applying to the wound a wound dressing comprising a wound dressing material comprising:
a wound dressing carrier;
N-acetyl cysteine or a salt or derivative thereof; and
a stabilized ascorbate;
wherein the weight ratio of N-acetyl cysteine or a salt or derivative thereof to said stabilized ascorbate is from about 1:4 to about 4:1; and
wherein said stabilized ascorbate comprises ascorbate-2-triphosphate.
12. A method of making a wound dressing material comprising the steps of:
(a) dispersing one or more medically acceptable polymeric materials, N-acetyl cysteine or a salt or derivative thereof, and ascorbic acid or a salt or derivative thereof in an aqueous solvent to form an aqueous dispersion; and
(b) freeze-drying or solvent-drying the aqueous dispersion to produce the wound dressing material;
wherein the weight ratio of N-acetyl cysteine or a salt or derivative thereof to said ascorbic acid or a salt or derivative thereof is from about 1:4 to about 4:1; and
wherein said stabilized ascorbate comprises ascorbate-2-triphosphate.
13. The method of claim 8 , wherein the wound dressing comprises from about 0.1 wt. % to about 20 wt. % of said N-acetyl cysteine or salts or derivatives thereof, and from about 0.1 wt. % to about 20 wt. % of said stabilized ascorbate.
14. The method of claim 8 , wherein the carrier comprises a woven or nonwoven fabric, a foam, a freeze-dried or solvent-dried sponge, or a solid film.
15. The wound dressing material of claim 1 , wherein the carrier is bioabsorbable and provides sustainable release of ascorbic acid and N-acetyl cysteine to a wound.
16. A wound dressing according to claim 9 , wherein the wound dressing carrier is bioabsorbable.
17. A wound dressing according to claim 9 , wherein the material comprises from about 1 wt. % to about 10 wt. % of said N-acetyl cysteine or salts or derivatives thereof, and from about 1 wt. % to about 10 wt. % of said stabilized ascorbate.
18. A wound dressing according to claim 17 , wherein the carrier consists essentially of a freeze-dried sponge, or a solvent-dried sponge.
19. A wound dressing material according to claim 18 , wherein the wound dressing carrier is bioabsorbable.
20. A wound dressing according to claim 18 , wherein said sponge carrier comprises oxidized cellulose, in combination with collagen or chitosan.