Oxazolidinone derivatives

1. A compound of formula (I)

wherein

Y represents CH 2 , CHR 1 , or CR 1 R 2 ; wherein

R 1 and R 2 independently represent (C 1-4 )alkyl;

R 3 represents Ar 1 or Ar 3 —Z—Ar 2 —* wherein the asterisk indicates the bond that is attached to the rest of the molecule; wherein

Ar 1 represents aryl or heteroaryl, wherein the aryl or heteroaryl is independently unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, (C 1-3 )fluoroalkyl-thio-, and (C 3-6 ) cycloalkyl-(C 1-4 )alkoxy;

Ar 2 represents phenyl or 5- to 6-membered heteroaryl;

Z represents a bond, O, or —CH 2 —O—* wherein the asterisk indicates the bond that is attached to Ar 2 ;

Ar 3 represents phenyl or 5- to 6-membered heteroaryl wherein the phenyl or 5- to 6-membered heteroaryl is independently unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 ) fluoroalkoxy; and

R 4 represents aryl or heteroaryl, wherein the aryl or heteroaryl is independently mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy-(C 1 4alkoxy, and (C 1-4 )alkoxy-(C 1-4 )alkoxy; wherein, in the specific case wherein said aryl or heteroaryl is a bicyclic ring, the aryl or heteroaryl may also be unsubstituted;

with the exception of the following compounds:

2-(2-bromophenyl)-3-[(4-methoxyphenyl)methyl]-4-oxazolidinone;

2-(2-bromophenyl)-3-{[4-(trifluoromethyl)phenyl]methyl}-4-oxazolidinone;

2-(2-bromophenyl)-3-(phenylmethyl)-4-oxazolidinone; and

2-(4-methoxyphenyl)-3-[(4-methoxyphenyl)methyl]-5-methyl-4-oxazolidinone;

in a free or a pharmaceutically acceptable salt.

2. The compound according to claim 1 ; wherein Y represents CHR 1 , or CR 1 R 2 ;

in a free or a pharmaceutically acceptable salt.

3. The compound according to claim 1 ; wherein

Ar 1 represents aryl which is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, (C 1-3 )fluoroalkyl-thio-, and (C 3-6 )cycloalkyl-(C 1-4 )alkoxy; or

Ar 1 represents heteroaryl which is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy and (C 1-3 )fluoroalkyl;

in a free or a pharmaceutically acceptable salt.

4. The compound according to claim 1 ; wherein, in case Ar 1 represents aryl, said aryl is

phenyl which is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, (C 1-3 )fluoroalkyl-thio-, and (C 3-6 )cycloalkyl-(C 1-4 )alkoxy; or

naphthyl which is unsubstituted, or mono-, or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; or

a phenyl ring fused to a 5- or 6-membered saturated or partially unsaturated non-aromatic ring optionally containing 1 to 2 oxygen atoms which is unsubstituted, or mono-, or di-substituted wherein the substituents are independently selected from the group consisting of methyl, methoxy, and halogen;

in a free or a pharmaceutically acceptable salt.

5. The compound according to claim 1 ; wherein Z represents a O; in a free or a pharmaceutically acceptable salt.

6. The compound according to claim 1 ; wherein

Ar 3 represents phenyl which is unsubstituted, or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; or

Ar 3 represents 5- to 6-membered heteroaryl which is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

in a free or a pharmaceutically acceptable salt.

7. The compound according to claim 1 ; wherein R 3 represents

phenyl which is mono-, or di-substituted, wherein one substituent is (C 1-4 )alkoxy, or (C 1-3 )fluoroalkoxy in position 4 of said phenyl and the other (if present) is selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; or

Ar 3 —Z—Ar 2 —* wherein the asterisk indicates the bond that is attached to the rest of the molecule; wherein

Ar 2 represents phenyl or 6-membered heteroaryl which are substituted by Z and the rest of the molecule in a para arrangement,

Z represents O, and

Ar 3 represents phenyl or 5- to 6-membered heteroaryl wherein the phenyl or 5- to 6-membered heteroaryl is independently unsubstituted or mono-substituted, wherein the substituent is independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

in a free or a pharmaceutically acceptable salt.

8. The compound according to claim 1 ; wherein

R 4 represents aryl which is mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy-(C 1-4 alkoxy, and (C 1-4 )alkoxy-(C 1-4 )alkoxy; wherein, in the specific case wherein said aryl is a bicyclic ring, the aryl may also be unsubstituted; or

R 4 represents heteroaryl which is mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy-(C 1-4 ) alkoxy, and (C 1-4 )alkoxy-(C 1-4 )alkoxy; wherein, in the specific case wherein said heteroaryl is a bicyclic ring, the heteroaryl may also be unsubstituted;

in a free or a pharmaceutically acceptable salt.

9. The compound according to claim 1 ; wherein, in case R 4 represents aryl, said aryl is

phenyl which is mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy-(C 1-4 )alkoxy, and (C 1-4 )alkoxy-(C 1-4 )alkoxy; or

naphthyl which is unsubstituted, or mono-, or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; or

a phenyl ring fused to a 5- or 6-membered saturated or partially unsaturated non-aromatic ring optionally containing 1 to 2 oxygen atoms which is unsubstituted, or mono-, or di-substituted wherein the substituents are independently selected from the group consisting of methyl, methoxy, and halogen;

in a free or a pharmaceutically acceptable salt.

10. A compound of formula (II)

wherein

Y 1 represents CH 2 , CH(CH 3 ) or CH(CH 3 ) 2 ;

R 13 represents

wherein

R 15 represents (C 1-4 )alkyl or (C 1-3 )fluoroalkyl;

V 1 , V 2 and V 4 are CH, and V 3 is CR 17 , wherein optionally one or two of V 1 , V 2 , V 3 and V4 may also be N; and

R 17 is hydrogen or halogen; or

R 15 represents phenyl or 5- to 6-membered heteroaryl, wherein the phenyl or 5- to 6-membered heteroaryl is independently unsubstituted, or mono-substituted, wherein the substituent is selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; and

one or two of V 1 , V 2 , V 3 and V 4 are CH or N and the remaining are CH; and

R 14 represents a group selected from the group consisting of:

wherein

W 1 represents CH and W 2 represents CR 17 or N, or

W 1 represents N and W 2 represents CH;

R 16 represents methyl, (C 1-3 )alkoxy, halogen, (C 1-2 )fluoroalkoxy, or trifluoromethyl;

R 17 represents hydrogen, methyl or fluoro; and

n represents the integer 1 or 2;

in a free or a pharmaceutically acceptable salt.

11. The compound according to claim 1 selected from the group consisting of:

3-(4-Chloro-3-trifluoromethyl-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-methyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-trifluoromethyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(3-methoxy-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(3-trifluoromethyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-trifluoromethoxy-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(3-trifluoromethoxy-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-fluoro-3-methyl-benzyl)-oxazolidin-4-one;

3-(3-Chloro-4-fluoro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-2-fluoro-5-trifluoromethyl-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-methyl-3-trifluoromethyl-benzyl)-oxazolidin-4-one;

3-(2-Chloro-5-trifluoromethyl-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-fluoro-5-trifluoromethyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-fluoro-3-trifluoromethyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(3-fluoro-4-trifluoromethyl-benzyl)-oxazolidin-4-one;

3-(2-Chloro-3,6-difluoro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(4-Chloro-3-fluoro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-4-trifluoromethoxy-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(4-Chloro-2-fluoro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-fluoro-benzyl)-oxazolidin-4-one;

3-(4-Chloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-fluoro-4-trifluoromethyl-benzyl)-oxazolidin-4-one;

3-(2,6-Dichloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(3-methyl-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-fluoro-benzyl)-oxazolidin-4-one;

3-(3,4-Difluoro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(4-methoxy-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-phenyl)-3-(2-methyl-5-trifluoromethyl-benzyl)-oxazolidin-4-one;

3-(3,4-Dichloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(2,4-Dichloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-4-methyl-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-trifluoromethyl-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(2-trifluoromethoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-trifluoromethoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(3-trifluoromethoxy-benzyl)-oxazolidin-4-one;

3-(3-Chloro-4-fluoro-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-2-fluoro-5-trifluoromethyl-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-fluoro-3-trifluoromethyl-benzyl)-oxazolidin-4-one;

3-(4-Chloro-3-fluoro-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-4-trifluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(2,4,6-trimethyl-benzyl)-oxazolidin-4-one;

3-(2,4-Dichloro-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

3-(3-Chloro-4-methyl-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(2,6-dimethyl-benzyl)-oxazolidin-4-one;

3-(2-Chloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

3-(2,5-Dichloro-benzyl)-2-(2-ethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(3-fluoro-4-trifluoromethoxy-benzyl)-oxazolidin-4-one;

3-(4-Difluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-(R)-5-methyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

3-(4-Difluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-(R)-5-methyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-(R)-5-methyl-3-naphthalen-2-ylmethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-propoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(3-fluoro-4-trifluoromethoxy-benzyl)-(R)-5-methyl-oxazolidin-4-one;

3-(3-Chloro-4-trifluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-(R)-5-methyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-naphthalen-2-ylmethyl-oxazolidin-4-one;

3-(3-Chloro-4-trifluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-5,5-dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-(S)-5-methyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-isopropoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-(4-trifluoromethoxy-benzyl)-oxazolidin-4-one;

3 -Benzothiazol-2-ylmethyl-2-(2,6-dimethoxy-phenyl)-(R)-5-methyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-(R)-5-methyl-3-(4-trifluoromethoxy-benzyl)-oxazolidin-4-one;

3 -Benzothiazol-2-ylmethyl-2-(2,6-dimethoxy-phenyl)-5,5-dimethyl-oxazolidin-4-one;

3-(4-Cyclopropylmethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-(S)-5-methyl-3-naphthalen-2-ylmethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(3-fluoro-4-trifluoromethoxy-benzyl)-5,5-dimethyl-oxazolidin-4-one;

3 -Benzooxazol-2-ylmethyl-2-(2,6-dimethoxy-phenyl)-5,5-dimethyl-oxazolidin-4-one;

3 -(4-Difluoromethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5 ,5 -dimethyl-3 -(1-methyl-1H-benzoimidazol-2-ylmethyl)-oxazolidin-4-one;

3 -Benzo [1,3]dioxol-5 -ylmethyl-2-(2,6-dimethoxy-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-methoxy-benzyl)-5,5-dimethyl-oxazolidin-4-one;

(R)-2-(2,6-Dimethoxy-phenyl)-5-methyl-3-(4-propoxy-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-isopropoxy-benzyl)-(R)-5-methyl-oxazolidin-4-one;

3 -(4-Cyclopropylmethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-(R)-5 -methyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-isopropoxy-benzyl)-5,5-dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-(4-propoxy-benzyl)-oxazolidin-4-one;

3 -(4-Cyclopropylmethoxy-benzyl)-2-(2,6-dimethoxy-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-ethoxy-benzyl)-(R)-5-methyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-3-(4-ethoxy-benzyl)-5,5-dimethyl-oxazolidin-4-one;

3 -(3 -Chloro-4-trifluoromethoxy-benzyl)-2-(2,6-dimethyl-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

3 -(3 -Chloro-4-trifluoromethoxy-benzyl)-2-(2,6-difluoro-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

3 -(3 -Chloro-4-trifluoromethoxy-benzyl)-2-(2-methoxy-6-methyl-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

2-(2-Fluoro-6-methoxy-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2-Chloro-6-methoxy-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2-Methoxy-6-trifluoromethyl-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

3 -Biphenyl-4-ylmethyl-2-(2,6-dimethoxy-phenyl)-5 ,5 -dimethyl-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-(4-trifluoromethylsulfanyl-benzyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-(6-phenoxy-pyridin-3-ylmethyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5 ,5 -dimethyl-3 -(5-phenoxy-pyridin-2-ylmethyl)-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-[4-(pyridin-2-yloxy)-benzyl]-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-[4-(pyrazin-2-yloxy)-benzyl]-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5 ,5-dimethyl-3-[4-(6-methyl-pyridazin-3-yloxy)-benzyl]-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-[4-(thiazol-2-yloxy)-benzyl]-oxazolidin-4-one;

2-(2,6-Dimethoxy-phenyl)-5,5-dimethyl-3-[4-(pyrimidin-2-yloxy)-benzyl]-oxazolidin-4-one;

2-(2-Isopropoxy-6-methoxy-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-(2-Ethoxy-6-methoxy-phenyl)-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

2-[2-Methoxy-6-(2-methoxy-ethoxy)-phenyl]-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one; and

2-[2-(3-Hydroxy-propoxy)-6-methoxy-phenyl]-5,5-dimethyl-3-(4-phenoxy-benzyl)-oxazolidin-4-one;

in a free or a pharmaceutically acceptable salt.

12. The pharmaceutical composition containing, as active principle, the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

13. A method for the treatment of a disease or disorder wherein the compound of claim 1 is administered to a patient in need therof, wherein said disease or disorder is an insomnia.

14. A method for the treatment of a disease or disorder wherein the compound of claim 10 is administered to a patient in need thereof, wherein said disease or disorder is an insomnia.

15. A pharmaceutical composition comprising a compound according to claim 10 , in a free or pharmaceutically acceptable salt form, and a pharmaceutically acceptable carrier.