Multicomponent degradable cationic polymers
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
1. A compound of Formula (I):
wherein:
each m is independently an integer selected from the group consisting of 3, 4, 5, 6, and 8;
n is an integer from 1 to 10,000;
R′ is a side chain comprising a functional group selected from the group consisting of —OH, —NH 2 and —SH; and
R″ is selected from the group consisting of:
and
pharmaceutically acceptable salts thereof.
2. The compound of claim 1 , wherein n is an integer selected from the group consisting of: an integer from 1 to 1,000; an integer from 1 to 100; an integer from 1 to 30; an integer from 5 to 20; an integer from 10 to 15; and an integer from 1 to 10.
3. The compound of claim 1 , wherein R′ is selected from the group consisting of:
4. The compound of claim 1 , wherein the compound of formula (I) has a structure selected from the group consisting of: