IP Library Granted Patent US 8,951,558
Granted Patent B2
US 8,951,558 · App. 13/322,530 · Granted Feb 10, 2015

Aqueous carbonated medium containing an amino(meth)acrylate polymer or copolymer

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Quick Facts
Patent No.
US 8,951,558
App. No.
13/322,530
Granted
Feb 10, 2015
Kind
B2
Abstract

The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in dematerialised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.

Claims (25)

1. An aqueous medium, comprising:

an amino(meth)acrylate polymer or copolymer which is not soluble in demineralised water, comprising polymerized units of 20-30% by weight of methyl methacrylate, 20-30% by weight of butyl methacrylate, and 60-40% by weight of dimethylaminoethyl methacrylate,

wherein the medium has a content of an aqueous phase of at least 60% by weight and a content of 10 to 22% by weight of the amino(meth)acrylate polymer or copolymer, and

wherein the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer present in solute form in the medium.

2. The aqueous medium of claim 1 , wherein the medium has a pH of 6.7 to 7.4.

3. The aqueous medium of claim 1 , wherein the amino(meth)acrylate polymer or copolymer content is 10 to 20% by weight.

4. The aqueous medium of claim 1 , wherein the medium has a viscosity of 5 to 150 mPa·s.

5. The aqueous medium of claim 1 , further comprising a pharmaceutical or a nutraceutical excipient.

6. The aqueous medium of claim 5 , wherein the pharmaceutical or nutraceutical excipient is at least one selected from the group consisting of an antioxidant, a brightener, a colorant, a flavouring agent, a flow aid, a fragrance, a glidant, a penetration-promoting agent, a pigment, a plasticizer, a pore-forming agent, and a stabilizer.

7. The aqueous medium of claim 6 , further comprising at least one selected from the group consisting of triethylcitrate and stearic acid.

8. The aqueous medium of claim 1 , wherein the medium is comprised in a container comprising a carbon dioxide atmosphere.

9. The aqueous medium of claim 1 , wherein the medium is comprised in a container comprising polyethylene or polyethylene terephthalate.

10. A process for preparing the aqueous medium of claim 1 , the process comprising: charging the aqueous phase with carbonic acid, to obtain a carbonic acid charged aqueous phase; and dissolving the amino(meth)acrylate polymer or copolymer which is not soluble in pure water but soluble in the carbonic acid charged aqueous phase.

11. The process of claim 10 , further comprising

charging the aqueous phase with carbonic acid up to a saturation point by contacting carbonic acid in a gas form with the aqueous phase at 25° C. and normal pressure conditions or under a pressure of up to 10 bar.

12. The process of claim 10 , further comprising,

charging the aqueous phase with carbonic acid up to a saturation point by contacting carbonic acid in a gas form with the aqueous phase in a pressure reactor at a pressure of 100 to 1000 mbar,

decreasing the pressure to normal conditions, and subsequently

dissolving and stirring the amino(meth)acrylate polymer or copolymer in the carbonated aqueous phase until the polymer or copolymer is dissolved completely.

13. A process of coating a pharmaceutical, nutraceutical, or cosmetical composition, the process comprising:

contacting the aqueous medium of claim 1 with a pharmaceutical, nutraceutical, or cosmetical composition,

wherein the pharmaceutical, nutraceutical, or cosmetical composition is in the form of a pellet, a granule, a minitablet, a tablet, or a capsule.

14. A process of binding a pharmaceutical, nutraceutical, or cosmetical composition, the process comprising:

contacting a binding solution comprising the aqueous medium of claim 1 with a pharmaceutical, nutraceutical, or cosmetical composition,

wherein the pharmaceutical, nutraceutical, or cosmetical composition is in the form of a pellet, a granule, a minitablet, a tablet, or a capsule.

Assignments (4)
CHANGE OF NAME Recorded Feb 11, 2020
From: EVONIK ROEHM GMBH
To: ROEHM GMBH
Reel/Frame 051893/0671 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2020
From: ROEHM GMBH
To: EVONIK DEGUSSA GMBH
Reel/Frame 051893/0727 →
CHANGE OF NAME Recorded Feb 11, 2020
From: EVONIK DEGUSSA GMBH
To: EVONIK OPERATIONS GMBH
Reel/Frame 051894/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2011
From: LIZIO, ROSARIO; DAMM, MICHAEL; PETEREIT, HANS-ULRICH
To: EVONIK ROEHM GMBH
Reel/Frame 027305/0709 →