Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use
Novel piperazine, piperidine and tetrahydropyridine derivatives comprising a dibenzofurane moiety are provided herein, as well as pharmaceutical compositions comprising same and therapeutic uses thereof.
1. A compound of the general formula:
wherein:
R 1 is hydroxy;
R 2 and R 3 are independently selected from the group consisting of C1-C5 alkyl, —OH, —SH, halogen, alkoxy, NO 2 , and —CN;
m is 1;
n is 0, 1, 2 or 3; and
p is 0, 1, 2, 3 or 4.
2. A pharmaceutical composition comprising a compound as defined in claim 1 in combination with one or more pharmaceutically acceptable carriers.
3. A method for treating CNS dyskinesia in mammals, comprising administering to said mammal a therapeutically effective amount of the compound defined in claim 1 .
4. A compound of formula I:
wherein:
Y 1 is N and Y 2 is independently CH, or N;
X is N;
R 1 , R 2 and R 3 are independently selected from the group consisting of C1-C5 alkyl, —OH, —SH, halogen, alkoxy, NO 2 , and —CN;
m is 1;
n is 0, 1, 2 or 3; and
p is 0, 1, 2, 3 or 4.
5. A compound according to claim 4 , having the formula Ib or Ic:
6. A compound according to claim 5 , wherein R 1 is selected from the group consisting of hydroxy, alkoxy, halogen and cyano.
7. A pharmaceutical composition comprising a compound as defined in claim 4 in combination with one or more pharmaceutically acceptable carriers.
8. A method for treating CNS dyskinesia in mammals, comprising administering to said mammal a therapeutically effective amount of the compound defined in claim 4 .