Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof

1. Compounds of formula (I)

or pharmaceutically acceptable salts thereof, having the subformula Ia, Ib or Id selected from the group consisting of:

or an N-oxide thereof,

wherein:

Y is absent or is selected from the group consisting of —C(═O)—, —N(H)C(═O)—, —N(R a )C(═O)—, —O—C(═O)—, —N(H)S(O) 1-2 —, —N(R a )S(O) 1-2 — and —S(O) 2 —, wherein R a is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 heteroalkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R 2 is —(X b ) 0-1 —R b , wherein X b is selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene, C 1-6 heteroalkylene, 3-6 membered cycloalkylene and 3-6 membered heterocycloalkylene, R b is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocycloalkyl, 6-10 membered aryl and 5-10 membered heteroaryl, wherein the aliphatic and aromatic portions of X b and R b are each independently optionally substituted with 1 to 5 R b1 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, F, Cl, Br, I, —OH, —NH 2 , —SH, —CN, —NO 2 , —N 3 , —C(═O)OH, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, —(C 1-4 alkenylene) 0-1 -C(═O)—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)O—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)N(H)—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)N(C 1-4 alkyl) 2 , —(C 1-4 alkenylene) 0-1 -S(O) 2 —(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)—(C 1-4 heteroalkyl) and —(C 1-4 alkenylene) 0-1 -C(═O)—(C 3-6 heterocycloalkyl), and wherein if R b is a 6 membered aryl or a 5-6 membered heteroaryl then any two substituents attached to adjacent atoms said aryl or heteroaryl are optionally combined to from a 3-6 membered carbocyclic or a 3-6 membered heterocyclic ring comprising 1-3 heteroatoms selected from N, O and S, and optionally substituted with 1 to 3 R b1 substituents;

X 1 is N or N + —O − ;

X 2 , X 3 and X 4 are each C, or one of X 2 , X 3 and X 4 is N or N + —O − and the remainder of X 2 , X 3 and X 4 are each C;

R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkyamino, F, Cl, Br, I, —CN, —CF 3 , —OCF 3 , —SF 5 and —N 3 ;

R 4 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, F, Cl, Br, I, —CN, —NO 2 , —N 3 , —SH, —OH, C 1-6 alkoxy, —CF 3 , —OCF 3 , —SF 5 , C 1-6 alkylamino and C 1-6 dialkylamino, or is absent if X 4 is N or N + —O;

R 5 is (X c ) 0-1 —R c , wherein X c is selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene, C 2-6 heteroalkylene, C 2-6 alkynylene, —N(H)—, —N(R xc )—, —O—, —S(O) 2 —, —C(═O)—, —C(═O)O—, —C(═O)N(H)—, —N(H)C(═O)— and —OC(═O)—, wherein R xc is selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, and wherein R c is selected from the group consisting of hydrogen, F, Cl, Br, I, —CN, —NO 2 , —NH 2 , —OH, —CF 3 , —OCF 3 , —SF 5 , C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocycloalkyl, 6 membered aryl and 5-6 membered heteroaryl, wherein the aliphatic and aromatic portions of X c and R c are optionally substituted with 1 to 5 R c1 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 heteroalkyl, F, Cl, Br, I, —OH, —NH 2 , —SH, —CN, —NO 2 , —N 3 , —C(═O)OH, —N(C 1-6 alkyl) 2 , —NH(C 1-6 alkyl), —O(C 1-6 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)O—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)N(H)—(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)N(C 1-4 alkyl) 2 , —(C 1-4 alkenylene) 0-1 -S(O) 2 —(C 1-4 alkyl), —(C 1-4 alkenylene) 0-1 -C(═O)—(C 1-4 heteroalkyl) and —(C 1-4 alkenylene) 0-1 -C(═O)—(C 3-6 heterocycloalkyl), or R 5 is absent if X 3 is N or N + —O − ;

R 6 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, C 2-6 alkenyl, C 2-6 alkynyl, F, Cl, Br, I, —OH, —NH 2 , —SH, —CN, —NO 2 , —CF 3 , —OCF 3 , —SF 5 and —N 3 , or R 6 is absent if X 2 is N or N + —O − ;

A is absent or is selected from the group consisting of —O—, —N(H)—, —N(R d )—, —S(O) 2 —, —S(O)—, —S—, —(X d ) 0-1 —N(H)C(═O)—, —(X d ) 0-1 —N(R d )C(═O)—, —X d —, —(X d ) 0-1 —C(═O)N(H)—, —(X d ) 0-1 —C(═O)N(R d )—, —(X d ) 0-1 —C(═O)—, —C(═O)—(X d ) 0-1 —, —(X d ) 0-1 —OC(═O)— and —(X d ) 0-1 C(═O)O—, wherein X d is selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene, C 1-6 heteroalkylene, 6-10 membered arylene, 5-10 membered heteroarylene, 3-10 membered cycloalkylene, 3-10 membered heterocycloalkylene, and R d at each occurrence is independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 1-6 heteroalkyl and C 1-6 haloalkyl, wherein the aliphatic or aromatic portions of X d and R d are each independently optionally substituted with 1 to 5 R d1 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylamino, C 1-6 dialkylamino, F, Cl, Br, I, —OH, —NH 2 , —SH, —CN, —NO 2 , —CF 3 , —OCF 3 , —SF 5 , and —N 3 ;

B is selected from the group consisting of 3-6 membered cycloalkyl, 4-9 membered heterocycloalkyl, 6-10 membered aryl and 5-6 membered heteroaryl, wherein the aliphatic or aromatic portions of B are independently optionally substituted with 1 to 5 R B1 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, C 3-6 heterocycloalkyl, F, Cl, Br, I, —OH, —NH 2 , —SH, —CF 3 , —OCF 3 , —SF 5 , —(X e ) 0-1 —CN, —(X e ) 0-1 —NO 2 , —(X e ) 0-1 —N 3 , —(X e ) 0-1 —OH, —(X e ) 0-1 —H, —(X e ) 0-1 —N(H)R e , —(X e ) 0-1 —N(R e ) 2 , —(X e ) 0-1 —SR e , —(X e ) 0-1 —C(O)R e , —(X e ) 0-1 —S(O) 2 R e , —(X e ) 0-1 —S(O)R e , —N(H)S(O) 2 R e , —N(R e )S(O) 2 R e , —(X e ) 0-1 —C(═O)OR e , —(X e ) 0-1 —C(═O)OH, —(X e ) 0-1 —C(═O)N(H)R e , —(X e ) 0-1 —C(═O)N(R e )R e , —(X e ) 0-1 —N(H)C(═O)R e , —(X e ) 0-1 —N(R e )C(═O)R e , wherein if B is a 6 membered aryl or a 5-6 membered heteroaryl then any two substituents attached to adjacent atoms of said aryl or heteroaryl are optionally combined to from a 3-6 membered carbocyclic or a 3-6 membered heterocyclic ring optionally comprising 1-3 heteroatoms selected from N, O and S, and optionally substituted with 1 to 3 R B1 substituents; wherein X e is selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene, C 1-6 heteroalkylene, C 3-6 cycloalkylene and C 3-6 heterocycloalkylene, and R e at each occurrence is independently selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3-7 membered cycloalkyl, 3-7 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, wherein the aliphatic or aromatic portions of X e and R e are each independently optionally substituted with 1 to 5 R e1 substituents selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylamino, C 1-6 dialkylamino, F, Cl, Br, I, —OH, —NH 2 , —SH, —CN, —NO 2 , —CF 3 , —OCF 3 , —SF 5 and —N 3 , and wherein any two R e groups attached to the same nitrogen atom are optionally combined to form a 3-7 membered heterocyclic or 5-10 membered heteroaryl ring comprising 1-3 heteroatoms selected from N, O and S; and

wherein if X 3 is N, R 3 is H, R 4 is H or NH 2 , R 6 is —OH and —Y—R 2 is other than H, then -A-B is not thiazol-4-yl substituted with 2-thiophenyl-S(O) 2 CH 2 —, phenyl-S(O) 2 —CH 2 —, 4-pyridyl, or pyridyl-S(O) 2 CH 2 —, if X 3 is N, R 3 is H or Cl, R 4 is H, R 6 is —OH, —NH 2 , or —NHCH 3 and —Y—R 2 is hydrogen, 4-tetrahydropyranyl, 4-((CH 3 CH 2 ) 2 N(CH 2 ) 3-4 O)-phenyl, (CH 3 CH 2 ) 2 N(CH 2 ) 4 —, 3-(4-methylpiperazinyl)-propyl or trifluoroacetyl, then -A-B is not 2-chlorophenyl, 2-methylphenyl, 2,6-dichlorophenyl, 3,5-dimethoxyphenyl, 3,4-dimethoxypheny, phenyl, 2-chloro-6-(2-ethoxyethoxy)phenyl, if X 3 is N, R 3 , R 4 and R 6 are each H, and —Y—R 2 is hydrogen, cyclohexyl, (CH 3 CH 2 ) 2 NCH 2 CH 2 —, CH 3 N(H)CH 2 CH 2 —, (CH 3 ) 2 NCH 2 CH 2 —, (CH 3 ) 3 CC(═O)— or 2-(4-morpholinyl)ethyl, then -A-B is not 3,4-dimethoxyphenyl or optionally substituted pyridine-2-on-3-yl, if X 4 is N, R 3 is H, R 5 is isopropyl, R 6 is methoxy, -A-B is propyl or isopropyl, then —Y—R 2 is other than optionally substituted pyridyl, if X 4 is N, R 3 , R 5 , R 6 are each H, -A-B is methyl, then —Y—R 2 is other than hydrogen, if R 3 , R 4 , R 5 and R 6 are each H, and —Y—R 2 is hydrogen, cyclohexyl, (CH 3 CH 2 ) 2 NCH 2 CH 2 —, CH 3 N(H)CH 2 CH 2 —, (CH 3 ) 2 NCH 2 CH 2 —, (CH 3 ) 3 CC(═O)— or 2-(4-morpholinyl)ethyl, then -A-B is not 3,4-dimethoxyphenyl or optionally substituted pyridine-2-on-3-yl, if R 3 , R 4 and R 5 are each hydrogen, —Y—R 2 is other than hydrogen, then one of R 6 and -A-B is other than ethoxy.

2. The compound of claim 1 , wherein R 3 , R 4 and R 6 , if present, are each independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, —CF 3 , —OCF 3 , —SF 5 , F, Cl, Br and I.

3. The compound of claim 1 , wherein in R 2 , X b is absent or is selected from C 1-6 alkylene and 3-6 membered cycloalkylene; and R b is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocycloalkyl, 6-10 membered aryl, and 5-10 membered heteroaryl, wherein X b and R b are each independently optionally substituted.

4. The compound of claim 3 , wherein in R 2 , X b is absent.

5. The compound of claim 3 , wherein in R 2 , R b is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 2-6 alkenyl and C 2-6 alkynyl.

6. The compound of claim 3 , wherein in R 2 , R b is optionally substituted with from 1 to 5 R b1 groups selected from the group consisting of F, Cl, Br, I, OH, NH 2 , SH, CN, NO 2 , C 1-6 alkoxy, C 1-6 alkylamino and C 1-6 dialkylamino.

7. The compound of claim 1 , wherein in R 2 , R b is selected from the group consisting of cycloprop-1-yl, cyclobut-1-yl, cyclopent-1-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridin-2-yl, pyridin-4-yl, pyridin-3-yl, pyridin-2-on-6-yl, pyridine-2-on-5-yl, pyridine-2-on-4-yl, pyridine-2-on-3-yl, cyclohex-1-yl, phenyl, 4,5-dihydrooxazol-2-yl, oxazol-2-yl, piperidin-4-yl, piperidin-3-yl, piperidin-2-yl, piperidin-1-yl, piperazin-1-yl, piperazin-2-yl, piperazin-3-yl, morpholin-2-yl, morpholin-3-yl, morpholin-4-yl, tetrahydropyran-4-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl, oxetan-3-yl, oxetan-2-yl, pyrazol-5-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, methyl, ethyl, propyl, isopropyl, butyl, iso-butyl, tert-butyl, pyrrolidin-3-yl, pyrrolidin-2-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl and 3-oxabicyclo[3.1.0]hexan-6-yl, wherein said R b is further optionally substituted.

8. The compound of claim 1 , wherein Y is absent or is selected from the group consisting of —C(═O)—, —N(H)C(═O)—, —N(R a )C(═O)— and —S(O) 2 —.

9. The compound of claim 8 , wherein in R 2 , R b is selected from the group consisting of cycloprop-1-yl, cyclobut-1-yl, cyclopent-1-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridin-2-yl, pyridin-4-yl, pyridin-3-yl, pyridin-2-on-6-yl, pyridine-2-on-5-yl, pyridine-2-on-4-yl, pyridine-2-on-3-yl, cyclohex-1-yl, phenyl, 4,5-dihydrooxazol-2-yl, oxazol-2-yl, piperidin-4-yl, piperidin-3-yl, piperidin-2-yl, piperidin-1-yl, piperazin-1-yl, piperazin-2-yl, piperazin-3-yl, morpholin-2-yl, morpholin-3-yl, morpholin-4-yl, tetrahydropyran-4-yl, tetrahydropyran-2-yl, tetrahydropyran-3-yl, oxetan-3-yl, oxetan-2-yl, pyrazol-5-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, methyl, ethyl, propyl, isopropyl, butyl, iso-butyl, tert-butyl, pyrrolidin-3-yl, pyrrolidin-2-yl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl and 3-oxabicyclo[3.1.0]hexan-6-yl, and wherein in R 2 , R b is optionally substituted.

10. The compound of claim 9 , wherein the Y is —C(═O)—.

11. The compound of claim 7 , wherein in R 2 , R b is selected from the group as set forth on FIG. 1-A and FIG. 1-B .

12. The compound of claim 1 , wherein A is absent.

13. The compound of claim 1 , wherein A is present is selected from the group consisting of O—, —N(H)—, —N(R d )—, —S(O) 2 —, —S(O)— and —S—.

14. The compound of claim 1 , wherein A is present and is selected from the group consisting of —(X d ) 0-1 —N(H)C(═O)—, —(X d ) 0-1 —N(R d )C(═O)—, —X d —, —(X d ) 0-1 —C(═O)N(H)—, —(X d ) 0-1 —C(═O)N(R d )—, —(X d ) 0-1 —C(═O)—, —C(═O)—(X d ) 0-1 —, —(X d ) 0-1 —OC(═O)—, —(X d ) 0-1 C(═O)O— and wherein the X d group in A is selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene C 1-6 heteroalkylene, 6-10 membered arylene and a 5-10 membered heteroarylene comprising 1 to 3 heteroatoms selected from N, O and S, wherein said X d is optionally substituted.

15. The compound of claim 14 , wherein the X d group in A is selected from the group consisting of phenylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, and wherein said X d is optionally substituted.

16. The compound of claim 15 , wherein A is selected from the group consisting of

17. The compound of claim 1 , wherein A is selected from the group consisting of:

18. The compound of claim 1 , wherein B is selected from the group consisting of phenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, pyridin-4-on-3-yl, pyridin-4-on-2-yl, pyridin-4-on-1-yl, pyridin-2-on-1-yl, pyridin-2-on-3-yl, pyridin-2-on-4-yl, pyrrol-1-yl, pyrrol-3-yl, pyrrol-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyridazin-5-yl, pyrazin-2-yl, cyclohexyl, cyclobutyl, cyclopropyl, cyclopentyl, morpholin-4-yl, morpholin-2-yl, morpholin-3-yl, piperazin-1-yl, piperazin-2-yl, cyclopentyl, piperidin-1-yl, piperidin-4-yl, piperidin-2-yl, piperidin-3-yl, indol-5-yl, indol-4-yl, indol-3-yl, indol-2-yl, pyridimdin-5-yl, pyridimdin-4-yl, pyrimidin-2-yl, indazol-3-yl, indazol-4-yl, indazol-5-yl, indazol-6-yl, indazol-7-yl, indolin-2-on-4-yl, indolin-2-on-5-yl, indolin-2-on-6-yl, indolin-2-on-7-yl, tetrahydropyran-4-yl, tetrahydropyran-3-yl, tetrahydropyran-2-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrofuran-4-yl, wherein B is optionally substituted and wherein any two substituent located on adjacent atoms of B are optionally combined to form an optionally substituted 5 to 7 membered heterocyclic ring comprising 1 to 3 heteroatoms selected from N, O and S.

19. The compound of claim 15 , wherein B is selected from the group consisting of phenyl, pyridin-2-yl, pyridin-3-yl and pyridin-4-yl, wherein the B is optionally substituted with 1 to 3 R B1 substitutents selected from the group consisting of C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 heteroalkyl, C 1-6 alkoxy, C 1-6 alkylamino, C 1-6 dialkylamino, F, Cl, Br, I, —OH, —NH 2 , —SH, —(X e ) 0-1 —CN, —(X e ) 0-1 —NO 2 , —(X e ) 0-1 —N 3 , —(X e ) 0-1 —N(H)R e , —(X e ) 0-1 —N(R e ) 2 , —(X e ) 0-1 —SR e , —(X e ) 0-1 —C(O)R e , —(X e ) 0-1 —S(O) 2 R e , —(X e ) 0-1 —S(O)R e , —(X e ) 0-1 —C(═O)OR e , —(X e ) 0-1 —C(═O)N(H)R e , —(X e ) 0-1 —C(═O)N(R e )R e , —(X e ) 0-1 —N(H)C(═O)R e and —(X e ) 0-1 —N(R e )C(═O)R e , and wherein any two substituent located on adjacent atoms of B are optionally combined to form an optionally substituted 5 to 7 membered heterocyclic ring comprising 1 to 3 heteroatoms selected from N, O and S.

20. The compound of claim 17 , wherein B is selected from the group consisting of

21. The compound of claim 1 , wherein B is selected from the group consisting of:

22. The compound of claim 1 , wherein R 5 is (X c )—R c , wherein X c is absent or is selected from the group consisting of C 1-6 alkylene, —N(H)—, —N(R xc )—, —O—, —S(O) 2 —, and R c is selected from the group consisting of hydrogen, F, Cl, Br, I, —CN, —NO 2 , —CF 3 , —OCF 3 , —SF 5 , C 1-6 alkyl, C 1-6 heteroalkyl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, cyclopropyl, cyclopentyl, phenyl, pyridin-2-yl, pyridin-3-yl, pyridine-4-yl, pyrazol-4-yl, pyrazol-5-yl, thiazol-2-yl, thiazol-3-yl, thiazol-5-yl, piperazin-1yl, piperazin-2-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, pyrroldin-3-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, wherein R c is optionally substituted.

23. A compound of formula I selected from the group consisting of:

N-(7-(piperidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

7-(2-chlorophenyl)-N-(pyrimidin-2-yl)isoquinolin-3-amine;

7-(2-chlorophenyl)-N-(pyridin-2-yl)isoquinolin-3-amine;

7-(2-chloro-5-fluorophenyl)-N-(methylthiomethyl)isoquinolin-3-amine;

7-(2-chloro-5-fluorophenyl)-N-methylisoquinolin-3-amine;

N-(7-(5-chloro-2-methoxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

7-(5-fluoro-2-methylphenyl)isoquinolin-3-amine;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclobutanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopentanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclohexanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)benzamide;

4-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)benzamide;

1-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1-methylcyclopropanecarboxamide;

2-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

2,2-difluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2,5-dimethylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(6-aminopyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-cyanopyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

2-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-cyano-5-fluoropyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-chloro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-chloro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methoxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-isopropoxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3,5-dimethyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chloro-5-hydroxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4,5-difluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-4,4-dimethyl-4,5-dihydrooxazol-2-amine;

N-(7-(pyrrolidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-cyclohexylisoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methylpiperazin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-cyclopentylisoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)isonicotinamide;

2-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)benzamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-4-methoxybenzamide;

N-(7-(3-methylpyridin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1H-indol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-hydroxypiperidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(piperazin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1-methyl-6-oxo-1,6-dihydropyridin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)acetamide;

3,3,3-trifluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)propanamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)pivalamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methoxyacetamide;

N-(7-(5-cyano-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-cyano-6-methoxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(pyridin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1R,2R)-2-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

2-(dimethylamino)-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)acetamide;

1-ethyl-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1H-pyrazole-5-carboxamide;

3-fluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)benzamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methoxybenzamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-methoxybenzamide;

N-(7-(1H-indol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-cyano-4,5-difluorophenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-hydroxy-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)propionamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)isobutyramide;

N-(7-(pyrimidin-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4,6-dimethylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-methylthiazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1H-pyrazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

2,2,2-trifluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)acetamide;

N-(7-(2-cyano-5-fluorophenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-chloro-2-cyanophenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-cyano-4-fluorophenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

2,2-difluoro-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)acetamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)methanesulfonamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanesulfonamide;

1-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-methylurea;

N-(7-(phenylamino)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methylpyrimidin-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-methoxy-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-methyl-5-(trifluoromethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(dimethylamino)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-methylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1,1-dimethylurea;

N-(7-(2,4-dimethylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4,6-dimethylpyrimidin-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1-methyl-1H-pyrazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoropyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1-hydroxycyclopropanecarboxamide;

N-(7-(1H-pyrrol-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-cyano-5-hydroxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-hydroxy-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

7-(5-fluoro-2-methylphenyl)-N-(1,1,1-trifluoropropan-2-yl)isoquinolin-3-amine;

N-(cyclopropylmethyl)-7-(5-fluoro-2-methylphenyl)isoquinolin-3-amine;

4-chloro-7-(5-fluoro-2-methylphenyl)isoquinolin-3-amine;

N-(7-(4-fluoro-5-hydroxy-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(hydroxymethyl)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-fluoro-3-hydroxyphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylbenzamide;

1-ethyl-3-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)urea;

N-(4-chloro-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

2-fluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methyl-1H-pyrazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(4-bromo-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

1-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-(2-methoxyethyl)urea;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)piperidine-4-carboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-1-methylpyrrolidine-3-carboxamide;

1-ethyl-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)piperidine-4-carboxamide;

1-methyl-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide;

N-(4-fluoro-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

1-(4-chloro-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-ethylurea;

1-ethyl-3-(4-fluoro-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)urea;

2-cyclopropyl-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)acetamide;

(2-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-ylamino)pyridin-4-yl)methanol;

N-(7-(pyrazin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-methylpyrazin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

1-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-isopropylurea;

1-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-oxetan-3-yl)urea;

6-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-ylamino)pyridin-2(1H)-one;

N-(7-(5-fluoro-6-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(2-hydroxypropan-2-yl)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

7-(5-fluoro-2-methylphenyl)-N-(6-methoxypyridin-2-yl)isoquinolin-3-amine;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-4-methylpiperazine-1-carboxamide;

N-(7-(2,5-dimethylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-methylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

1-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)urea;

N-(7-(1H-indazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1H-indazol-6-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(pyridazin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-methylpyrazin-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;

3-chloro-N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;

isopropyl 7-(5-fluoro-2-methylphenyl)isoquinolin-3-ylcarbamate;

N-(7-(5-aminopyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-aminopyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(6-chloro-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-chloropyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1-methyl-1H-indazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-oxoindolin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-phenylcyclopropanecarboxamide;

(2-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-ylamino)-6-methylpyridin-4-yl)methanol;

2-(2-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-ylamino)-6-methylpyridin-4-yl)propan-2-ol;

N-(7-(6-amino-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(2-(7-(4-methylpyridin-3-yl)isoquinolin-3-ylamino)pyridin-4-yl)methanol;

N-(7-(5-(hydroxymethyl)-2-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(1-hydroxyethyl)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-(hydroxymethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chloro-5-(hydroxymethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-fluoro-5-(hydroxymethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)—N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methylcyclopropanecarboxamide;

(1S,2R)—N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methylcyclopropanecarboxamide;

(1R,2S)—N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methylcyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1-methyl-1H-pyrazole-4-carboxamide;

N-(7-(2-(hydroxymethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-2-methylisonicotinamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)tetrahydro-2H-pyran-4-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1-methylpiperidine-4-carboxamide;

(1R,2R)—N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)-2-methylcyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-((dimethylamino)methyl)benzamide;

N-(7-(5-amino-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-hydroxy-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(6-(hydroxymethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2-(hydroxymethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-hydroxypyrrolidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3-(aminomethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(hydroxymethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-(1-(dimethylamino)ethyl)benzamide;

(6-(7-(4-methylpyridin-3-yl)isoquinolin-3-ylamino)pyridin-2-yl)methanol;

N-(7-(4-(hydroxymethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(4-chloro-3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)phenyl)tetrahydro-2H-pyran-4-carboxamide

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-fluorophenyl)tetrahydro-2H-pyran-4-carboxamide;

N-(6-o-tolylisoquinolin-3-yl)cyclopropanecarboxamide;

(R)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)tetrahydrofuran-2-carboxamide;

(S)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)tetrahydrofuran-2-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-fluorophenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;

N-(4-chloro-3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)cyclobutanecarb(R)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)tetrahydrofuran-3-carboxamide;

(S)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)tetrahydrofuran-3-carboxamide;

N-(7-(6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

5-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-N,4-dimethylpicolinamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)morpholine-4-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-methylmorpholine-2-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)pyrrolidine-1-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-2-(hydroxymethyl)morpholine-4-carboxamide;

N-(7-(4-(trifluoromethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-6-(hydroxymethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(6-methoxy-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-(1-methylpyrrolidin-2-yl)benzamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-4-(1-methylpyrrolidin-3-yl)benzamide;

N-(7-(2-amino-4-methylpyrimidin-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(5-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylpyridin-3-yl)tetrahydro-2H-pyran-4-carboxamide;

7-(4-methylpyridin-3-yl)isoquinolin-3-amine;

(R)—N-(7-(6-(1-hydroxypropyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)—N-(7-(6-(1-hydroxypropyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1,4-dioxane-2-carboxamide;

(R)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1,4-dioxane-2-carboxamide;

N-(7-(5-amino-2-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(R)—N-(7-(6-(1-hydroxyethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)—N-(7-(6-(1-hydroxyethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(5-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-6-methylpyridin-3-yl)tetrahydro-2H-pyran-4-caN-(7-(5-methyl-1H-indazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-aminoisoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide;

(1R,2R)-2-fluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)-3-oxabicyclo[3.1.0]hexane-6-carboxamide;

N-(7-(2-fluoro-5-methylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(2,5-dimethylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)benzamide;

N-(7-(1H-pyrazolo[3,4-c]pyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

2-(4-((dimethylamino)methyl)phenyl)-N-(7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(2-methoxyacetamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

(R)—N-(7-(5-(2-methoxypropanamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)—N-(7-(5-(2-methoxypropanamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(1H-benzo[d]imidazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(2-methoxy-2-methylpropanamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(oxetan-3-yl)benzamide;

N-(5-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-6-methylpyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide;

N-(7-(5-(ethylsulfonamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1-hydroxycyclobutanecarboxamide;

N-cyclopropyl-7-(5-fluoro-2-methylphenyl)isoquinoline-3-carboxamide;

(S)—N-(7-(4-methyl-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(R)—N-(7-(4-methyl-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methoxypyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(cyclopentanesulfonamido)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)azetidine-1-carboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-1,1-dioxo-1-thiomorpholine-4-carboxamide;

(R)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide;

(S)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide;

(R)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-3-hydroxypyrrolidine-1-carboxamide;

(S)—N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)-3-hydroxypyrrolidine-1-carboxamide;

N-(7-(2-(hydroxymethyl)-5-methylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(5-hydroxy-2-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(R)-2,2-difluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)-2,2-difluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2R)-2-fluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1R,2S)-2-fluoro-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(1-methylcyclobutyl)benzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(1,1-dioxo-3-methyltetrahydrothiophen-3-yl)benzamide;

N-cyclopentyl-3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylbenzamide;

(S)-3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(tetrahydrofuran-3-yl)benzamide;

(R)-3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(tetrahydrofuran-3-yl)benzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-N-(2-methoxyethyl)-4-methylbenzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(1-methyl-1H-pyrazol-4-yl)benzamide;

N-(7-(2-methyl-5-(morpholine-4-carbonyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(7-(3,5-dimethylpyridin-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-amino-7-(4-methylpyridin-3-yl)isoquinoline-4-carbonitrile;

N-(4-cyano-7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

5-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylpicolinic acid;

N-cyclobutyl-7-(5-fluoro-2-methylphenyl)isoquinoline-3-carboxamide;

N-(7-(6-(hydroxy(2H2)methyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-5-fluoro-4-methyl-N-(oxetan-3-yl)benzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-2-fluoro-4-methyl-N-(oxetan-3-yl)benzamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-2-fluoro-4-methyl-N-(tetrahydro-2H-pyran-4-yl)benzamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-5-fluoro-4-methylphenyl)cyclobutanecarboxamide;

N-(7-(4-(2-hydroxyprop an-2-yl)-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide;

N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-2-fluoro-4-methylphenyl)cyclobutanecarboxamide;

3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(3-methyloxetan-3-yl)benzamide;

3-(3-((1S,2S)-2-fluorocyclopropanecarboxamido)isoquinolin-7-yl)-4-methyl-N-(3-methyloxetan-3-yl)benzamide;

2-fluoro-N-(7-(4-methyl-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methyl-6-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

1-methyl-3-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)urea;

N-(7-(2-chloro-5-fluorophenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-chloro-7-(2-chlorophenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chlorophenyl)-5-methyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chlorophenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chlorophenyl)-8-hydroxy-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

3-(2-chlorophenyl)-7-(cyclopropanecarboxamido)-2,6-naphthyridine 2-oxide;

N-(7-(2-chlorophenyl)-5-methoxy-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chlorophenyl)-5-ethyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(2-chlorophenyl)-5-cyclopropyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-cyclohexyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(4-methylpyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

7-(cyclopropanecarboxamido)-3-(5-fluoro-2-methylphenyl)-1-methyl-2,6-naphthyridine 2-oxide;

7-(cyclopropanecarboxamido)-3-(5-fluoro-2-methylphenyl)-2,6-naphthyridine 2-oxide;

N-(7-(5-fluoro-2-methylphenyl)-5-methyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-cyano-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(piperidin-1-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-(cyclopentyloxy)-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(hydroxymethyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-phenoxy-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(pyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(phenylamino)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-(cyclopentylamino)-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(fluoromethyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(1-methyl-1H-pyrazol-5-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(methylsulfonyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-phenyl-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-(2,4-dimethylthiazol-5-yl)-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(4-methylpyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(pyridin-4-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(1H-pyrazol-5-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(1-methyl-1H-pyrazol-4-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(1H-pyrazol-4-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(2-hydroxypropan-2-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-(hydroxymethyl)-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(piperidin-4-yloxy)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(5-((dimethylamino)methyl)-7-(5-fluoro-2-methylphenyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(piperazin-1-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-((methylamino)methyl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(pyrrolidin-3-yloxy)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

N-(7-(5-fluoro-2-methylphenyl)-5-(tetrahydrofuran-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methylpyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(5-methyl-1H-indazol-4-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

3-(7-((1S,2S)-2-fluorocyclopropanecarboxamido)-2,6-naphthyridin-3-yl)-4-methyl-N-(3-methyloxetan-3-yl)benzamide;

N-(2-(2,6-dichlorophenyl)-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

(3-(2-(2-chlorophenyl)-1,7-naphthyridin-6-ylamino)phenyl)methanol;

N-(2-(2-chlorophenyl)-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

N-(2-(2-chloro-5-fluorophenyl)-3-methyl-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

N-(2-(5-fluoro-2-methylphenyl)-4-methyl-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

N-(2-(1-hydroxycyclohexyl)-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

N-(2-(1-hydroxycyclopentyl)-1,7-naphthyridin-6-yl)cyclopropanecarboxamide;

Cyclopropanecarboxylic acid [7-(2-chloro-4-methyl-pyrimidin-5-yl)-isoquinolin-3-yl]-amide;

(R)—N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)oxetane-2-carboxamide;

(S)—N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)oxetane-2-carboxamide;

Cyclopropanecarboxylic acid [7-(2-chloro-4,6-difluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-3,6-difluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-fluoro-6-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-6-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2,5-difluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2,6-difluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(5-fluoro-2-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(5-chloro-2-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(3-chloro-pyridin-4-yl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid (7-pyridin-4-yl-isoquinolin-3-yl)-amide;

Cyclopropanecarboxylic acid (7-pyridin-3-yl-isoquinolin-3-yl)-amide;

Cyclopropanecarboxylic acid [7-(3-fluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(3-chloro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-5-fluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2,5-dichloro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2,6-dimethyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-6-trifluoromethyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-6-fluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-cyano-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid (7-o-tolyl-isoquinolin-3-yl)-amide;

Cyclopropanecarboxylic acid [7-(2-chloro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(2-fluoro-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid (7-phenyl-isoquinolin-3-yl)-amide;

Cyclopropanecarboxylic acid [7-(2,6-dichloro-phenyl)-isoquinolin-3-yl]-amide;

[7-(2,6-Dichloro-phenyl)-isoquinolin-3-yl]-[2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-amine;

[7-(2,6-Dichloro-phenyl)-isoquinolin-3-yl]-(2-morpholin-4-yl-pyrimidin-4-yl)-amine;

[7-(2,6-Dichloro-phenyl)-isoquinolin-3-yl]-(6-ethyl-2-morpholin-4-yl-pyrimidin-4-yl)-amine;

N-{7-[2,6-Difluoro-3-(propane-1-sulfonylamino)-phenyl]-isoquinolin-3-yl}-acetamide;

Cyclopropanecarboxylic acid [7-(3-fluoro-2-hydroxymethyl-6-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(5-fluoro-4-hydroxymethyl-2-methyl-phenyl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid {7-[5-fluoro-4-(1-hydroxy-1-methyl-ethyl)-2-methyl-phenyl]-isoquinolin-3-yl}-amide;

(1S,2S)—N-(7-(5-chloro-4-methyl-6-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamide;

(1S,2S)—N-(7-(5-chloro-4-methyl-6-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamide;

2-Fluoro-cyclopropanecarboxylic acid [7-(4-methyl-pyridin-3-yl)-[2,6]naphthyridin-3-yl]-amide;

2-Fluoro-cyclopropanecarboxylic acid [7-(4-methyl-pyridin-3-yl)-[2,6]naphthyridin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-fluoro-4-methyl-pyridin-3-yl)-5-methyl-[2,6]naphthyridin-3-yl]-amide;

2-Fluoro-cyclopropanecarboxylic acid [7-(2,4-dimethyl-azetidin-1-yl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(5-fluoro-4-methyl-pyridin-3-yl)-6-oxy-[2,6]naphthyridin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-fluoro-4-methyl-pyridin-3-yl)-[2,6]naphthyridin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(2-methoxy-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1R,2R)-2-Fluoro-cyclopropanecarboxylic acid [7-(4-methyl-pyridin-3-yl)-[2,6]naphthyridin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(1H-benzotriazol-4-yl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(6-fluoro-1H-indazol-4-yl)-isoquinolin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid {7-[5-fluoro-6-(1-hydroxy-1-methyl-ethyl)-4-methyl-pyridin-3-yl]-isoquinolin-3-yl}-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-fluoro-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-fluoro-2-hydroxymethyl-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(4-cyclopropyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-hydroxy-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

Cyclopropanecarboxylic acid [7-(3-methyl-1-oxy-pyridin-2-yl)-isoquinolin-3-yl]-amide;

2-Fluoro-cyclopropanecarboxylic acid [7-(6-methanesulfinyl-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1S,2S)—N-(7-(6-((R)-1-amino-2,2,2-trifluoroethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamide;

(1S,2S)—N-(7-(6-((S)-1-amino-2,2,2-trifluoroethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamideyl}-amide;

(1R,2R)-2-ethoxy-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-ethoxy-N-(7-(4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(2-((R)-1-hydroxyethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methyl-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methyl-2-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(2-((S)-1-hydroxyethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(S)—N-(7-(4-methyl-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)isobutyramide;

(R)—N-(7-(4-methyl-6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)isoquinolin-3-yl)isobutyramide;

(1S,2S)—N-(7-(6-(2,2-difluoro-1-hydroxyethyl)-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-((R)-2-methyl-5-oxopyrrolidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-[((S)-2-methyl-5-oxopyrrolidin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide;

3-[3-(Cyclopropanecarbonyl-amino)-isoquinolin-7-yl]-N-(3,3-difluoro-cyclobutyl)-4-methyl-benz amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid {7-[6-(1-hydroxy-1-methyl-ethyl)-4-methyl-pyridin-3-yl]-isoquinolin-3-yl}-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid {7-[6-(1-hydroxy-1-methyl-ethyl)-4-methyl-pyridin-3-yl]-[2,6]naphthyridin-3-yl}-amide;

(1S,2S)-2-fluoro-N-(7-(4-methyl-6-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

(1S,2S)-2-fluoro-N-(7-(4-methyl-6-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)-2,6-naphthyridin-3-yl)cyclopropanecarboxamide;

Cyclopropanecarboxylic acid [7-(4-methyl-1-oxy-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(4-methyl-pyridin-3-yl)-2-oxy-[2,6]naphthyridin-3-yl]-amide;

3-[3-(Cyclopropanecarbonyl-amino)-isoquinolin-7-yl]-N-(1-hydroxymethyl-cyclobutyl)-4-methyl-benzamide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(2-hydroxymethyl-4-methyl-pyridin-3-yl)-isoquinolin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(2-trifluoromethoxy-phenyl)-[2,6]naphthyridin-3-yl]-amide;

(1S,2S)-2-Fluoro-cyclopropanecarboxylic acid [7-(5-methyl-1H-indazol-4-yl)-isoquinolin-3-yl]-amide;

N-Cyclobutyl-3-[3-(cyclopropanecarbo(1S,2S)—N-(7-(5-chloro-6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-fluorocyclopropanecarboxamide;

3-(3-aminoisoquinolin-7-yl)-4-methyl-N-(1-methylcyclobutyl)benzamide;

3-(3-aminoisoquinolin-7-yl)-4-methyl-N-(3-methyloxetan-3-yl)benzamide;

5-(3-aminoisoquinolin-7-yl)-N-cyclobutyl-6-methylnicotinamide;

5-(3-aminoisoquinolin-7-yl)-6-methyl-N-(1-methylcyclobutyl)nicotinamide;

3-(3-aminoisoquinolin-7-yl)-2-fluoro-4-methyl-N-(3-methyloxetan-3-yl)benzamide and

3-(3-amino-4-chloroisoquinolin-7-yl)-4-methyl-N-(1-methylcyclobutyl)benzamidenyl-amino)-isoquinolin-7-yl]-4-methyl-benzamide.

24. A pharmaceutical composition comprising a compound in accordance with claim 1 and a pharmaceutically acceptable carrier, diluent or excipient.