IP Library › Granted Patent US 9,149,444
Granted Patent B2
US 9,149,444 · App. 13/326,180 · Granted Oct 6, 2015

Modulation of synaptic maintenance

Inventors: Ben A. Barres (Palo Alto, CA); Beth A. Stevens (Palo Alto, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
A61K31/00A61K31/727A61K45/06G01N33/5058G01N33/564G01N33/6872G01N33/6896A61K48/00G01N2333/4716G01N2500/04G01N2800/28G01N2800/2821
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Quick Facts
Patent No.
US 9,149,444
App. No.
13/326,180
Granted
Oct 6, 2015
Kind
B2
Abstract

C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.

Claims (4)

1. A method of treating glaucoma, the method comprising

administering a therapeutic amount of a complement inhibitor to a patient suffering from glaucoma to thereby treat the glaucoma, wherein the complement inhibitor is an anti-C1q antibody.

2. The method according to claim 1 , further comprising administering one or more neural progenitors or a neurogenesis enhancer.

3. The method of claim 1 , wherein said complement inhibitor inhibits complement activation.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 27, 2012
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028852/0764 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2012
From: BARRES, BEN A.; STEVENS, BETH A.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 027949/0303 →
Continuity (3)
Continuation 11636001 · Dec 8, 2006
Provisional Application 60749071 · Dec 9, 2005
Related Publication 20120195880A1 · Aug 2, 2012