Cadaveric allogenic human juvenile cartilage implant
View Patent ↗The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
1. A cartilage implant, comprising:
cadaveric allogenic human juvenile cartilage tissue particles including viable chondrocytes;
a first matrix comprising a biocompatible adhesive or sealant; and
a second matrix comprising collagen, polylactic acid or polyglycolic acid.
2. The implant of claim 1 , wherein the first matrix is selected from the group consisting of plasma-based adhesives or sealants, and protein-based adhesives or sealants, natural adhesives or sealants and any combination thereof.
3. The implant of claim 2 , wherein the first matrix is a plasma-based adhesive.
4. The implant of claim 3 , wherein the plasma-based adhesive comprises fibrin.
5. The implant of claim 1 , wherein the second matrix comprises collagen.
6. The implant of claim 5 , wherein the collagen is in the form of a fleece.
7. The implant of claim 1 , wherein the second matrix comprises polyglycolic acid.
8. The implant of claim 1 , wherein the cartilage particles are articular cartilage.
9. The implant of claim 1 , wherein the cartilage particles have a dimension from about one to about three millimeters.
10. The implant of claim 1 , wherein the cartilage particles range in size from about 1 to about 27 mm 3 .
11. The implant of claim 1 , wherein the cartilage particles are from donors less than fifteen years of age.
12. The implant of claim 11 , wherein the cartilage particles are from donors less than two years of age.
13. The implant of claim 11 , wherein the cartilage particles are from donors from about 20 weeks to about 13 years of age.
14. The implant of claim 1 , further comprising a retainer.
15. The implant of claim 14 , wherein the retainer comprises a physical attachment device.
16. The implant of claim 15 , wherein the physical attachment device is a tack or staple.
17. The implant of claim 8 , wherein the cartilage particles are from a femoral condyle, a tibial plateau or a patella.
18. The implant of claim 17 , wherein the cartilage particles are from a femoral condyle.