Granted Patent B2

US 12,383,190 · App. 13/333,235 · Granted Aug 12, 2025

Inventor: Ivan Osorio (Leawood, KS)

Assignee: FLINT HILLS SCIENTIFIC, LLC

A61B5/4094A61B5/0205A61B5/024A61B5/37A61B5/372A61B5/021A61B5/02405A61B5/08A61B5/11A61B5/1121A61B5/145A61B5/14546A61B5/4035A61B5/42A61B5/4836A61B5/4866A61B5/7275A61B2562/0219

Abstract

Claims (80)

1. A non-transitive computer readable program storage device encoded with instructions that, when executed by a computer, performs a method via one or more processors for identifying an extreme seizure event in a patient, comprising:

collecting body data from the patient using an electrical sensor;

identifying a first seizure event and a second seizure event from the collected body data;

determining a first inter-seizure interval value related to the first seizure event and a second inter-seizure interval value relating to the second seizure event;

comparing the determined of the first inter-seizure interval value and the second inter-seizure interval value to a population of patients;

determining a first severity of the first seizure event and a second severity of the second seizure event;

comparing the first severity and the second severity to the population of patients;

identifying an occurrence of the extreme seizure event based on the comparison of the first severity and the second severity to the population of patients;

setting a first flag indicative of the extreme seizure event;

providing a signal indicative of the extreme seizure event;

issuing a warning notice;

ranking the extreme seizure events;

initiating a logging sequence of the extreme seizure events;

initiating a reporting sequence for the extreme seizure events;

in response to the detection of the extreme seizure event, delivering at least one of an electrical therapy, a drug therapy, a thermal therapy, and an oxygen therapy;

determining after delivery of the therapy, the impact of the extreme seizure event on the patient; and

storing:

a time elapsed between at least one of a plurality of extreme or non-extreme seizure events and the identifying of the extreme seizure event;

differences in ranking between the identified extreme seizure event and:

a plurality of extreme seizure events;

a plurality of non-extreme seizure events;

the therapies used;

one or more parameters of the therapy used;

an effect of the therapy on the extreme seizure event;

a time at which the extreme seizure event was terminated;

a clinical outcome of the patient following the extreme seizure event;

a signal indicative of at least one of a time of day, a time of month, or a time of year;

whether the patient was awake or asleep at the time of the occurrence of the extreme seizure event;

a sleep stage of the patient at the time of the occurrence of the extreme seizure event.

2. The non-transitive computer readable program storage device of claim 1 , wherein the logging sequence of the method further comprises at least one of:

storing at least one of a start time of the extreme seizure event, an end time of the extreme seizure event, a duration of the extreme seizure event, a time and a date of the extreme event, a time of providing the therapies, and a time of issuing the warning notice into a memory of at least one medical device;

and

whether the patient was in a physical or cognitive sedentary state or active state wherein the physical or cognitive sedentary state includes at least one of a resting state or a mentally relaxing state, and wherein the active state includes at least one of the patient being physically and/or mentally active.

3. The non-transitive computer readable program storage device of claim 1 ,

wherein providing the therapy comprises providing at least one of:

an electrical therapy, a chemical therapy, or a thermal therapy; or

a supportive treatment comprising at least one of: providing fluids, providing tracheal intubation, providing body cooling, providing brain cooling, providing oxygen, or providing non-seizure drugs; and

wherein issuing the warning notice in the method indicates the increased risk to the health and/or the safety of the patient comprises emitting a sound, a light or a vibration to caregivers, or activating at least one of a notification to an emergency responder or a remote device to a care provider station.

4. The non-transitive computer readable program storage device of claim 1 , wherein the method further comprising:

requesting an extreme seizure event confirmation of the identifying the occurrence of the extreme seizure event;

receiving a response to the requesting; and

performing at least one of:

setting a second flag confirming the extreme seizure event if the response to the requesting indicates that the patient is having the extreme seizure event;

deactivating the first flag if the response indicates that the patient is not having the extreme seizure event;

cancelling at least one of the warning or the therapy in response to the deactivation;

logging an event as a false event or an unconfirmed event;

notifying at least one of the patient, a caregiver or an emergency responder that the warning notice was in response to the false event or the unconfirmed event; or

storing a signal indicative of at least one of:

a time of day, a time of month, or a time of year of the false event; or

whether the patient was awake or asleep at the time of the occurrence of the false event, and if the patient was a wake whether the patient was in a physical or cognitive sedentary state or active state wherein the physical or cognitive sedentary state includes at least one of a resting state or a mentally relaxing state, and wherein the active state includes at least one of the patient being physically and/or mentally active;

wherein when the patient is in the sleep condition collecting data relating to a stage of sleep.

5. The non-transitive computer readable program storage device of claim 1 , wherein the method further comprising determining a time spent in the extreme seizure event.

6. The non-transitive computer readable program storage device of claim 1 , wherein the method further comprising identifying a pathophysiological effect of the extreme seizure event selected from a group consisting of:

damage to brain tissue resulting in permanent or serious motor, visual, sensory, or cognitive skills;

a respiratory failure;

a respiratory distress syndrome;

a pulmonary edema;

a cardiac arrhythmia, a cardiac failure, an arterial hypertension or an arterial hypotension;

a metabolic acidosis;

a liver failure or a renal failure;

one or more bone fractures;

one or more skin abrasions;

one or more bruises, wounds or burns; or

an organ failure.

7. The non-transitive computer readable program storage device of claim 1 , wherein an onset and a termination of an ictal period or of the post-ictal period is determined in the method using at least one of a neurologic index selected from brain energy, a level of consciousness, complex reaction response times, and a kinetic activity, or an autonomic index selected from a heart rate, a heart rate variability, a cardiac cycle morphology, a respiratory rate, a tidal volume, a respiratory cycle morphology, an oxygen saturation, and an end tidal CO2.

8. The non-transitive computer readable program storage device of claim 1 , wherein the method further comprises:

determining a risk of death in response to identifying the occurrence of the extreme seizure event, wherein determining the risk comprises determining:

a decreasing heart rate variability (HRV);

an ST complex elevation;

an ST complex depression;

an QT elongation;

a multi-focal premature ventricular contraction (PVC);

a ventricular tachycardia;

a ventricular fibrillation;

a pulmonary hypertension;

an arterial hypotension; or

a respiratory distress syndrome;

issuing a risk warning of the risk of death in response to determining the risk of death; and

increasing the provided therapy in response to determining the risk of death.

9. The non-transitive computer readable program storage device of claim 1 , wherein a state of a patient's overall health and a body state are determined in response to a seizure severity index exceeding a reference value.

Assignments (1)

Continuity (2)

References Cited (400)