Anti-constipation composition
View Patent ↗An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in ratio of bi-cyclic/mono-cyclic structure of at least 1:1. The halogenated-bi-cyclic compound is represented by Formula (I): where X 1 and X 2 are preferably both fluorine atoms. The composition can be used to treat constipation with out substantive side-effects, such as stomachache.
1. A liquid dosage form for oral administration comprising:
a bi-cyclic compound represented by the formula (I),
a compound which is a mono-cyclic tautomer of formula (I), and
a non-aqueous solution or suspension agent,
wherein the non-aqueous solvent or suspending agent stabilizes the dosage form in a ratio of bi-cyclic compound to mono-cyclic tautomer of at least 20:1.
2. The liquid dosage form of claim 1 , wherein the non-aqueous solution or suspension agent is propylene glycol, polyethylene glycol, alcohol, or polysorbate.
3. The liquid dosage form of claim 1 , wherein the non-aqueous solution or suspension agent is propylene glycol, polyethylene glycol, a fatty acid triglyceride, a vegetable oil, or an alcohol.
4. The liquid dosage form of claim 1 , further comprising one or more of a preservative, wetting agent, emulsifier, dispersant, or anti-oxidant.
5. The liquid dosage form of claim 1 , wherein the ratio of bi-cyclic compound to mono-cyclic tautomer is at least about 96:4.
6. The liquid dosage form of claim 1 , which is formulated in a capsule.
7. The liquid dosage form of claim 6 , which is formulated in a soft capsule.