Anti-CD38 antibodies
View Patent ↗Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.
1. The isolated antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising:
a) a heavy chain variable region comprising:
i) a first CDR comprising SEQ ID NO:3;
ii) a second CDR comprising SEQ ID NO:4;
iii) a third CDR comprising SEQ ID NO:5; and
b) a light chain variable region comprising:
i) a first CDR comprising SEQ ID NO:6;
ii) a second CDR comprising SEQ ID NO:7;
iii) a third CDR comprising SEQ ID NO:8.
2. The isolated antibody according to claim 1 wherein said heavy chain variable region comprises SEQ ID NO:9.
3. The isolated antibody according to claim 1 wherein said light chain variable region comprises SEQ ID NO:10.
4. The isolated antibody according to claim 1 wherein said heavy chain variable region comprises SEQ ID NO:9 and said light chain variable region comprises SEQ ID NO:10.
5. The isolated antibody according to claim 1 wherein the heavy chain comprises SEQ ID NO:21 and the light chain comprises SEQ ID NO:22.
6. The isolated antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising:
a) a heavy chain variable region comprising:
i) a first CDR comprising SEQ ID NO:13;
ii) a second CDR comprising SEQ ID NO:14;
iii) a third CDR comprising SEQ ID NO:15; and
b) a light chain variable region comprising:
i) a first CDR comprising SEQ ID NO:16;
ii) a second CDR comprising SEQ ID NO:17;
iii) a third CDR comprising SEQ ID NO:18.
7. The isolated antibody according to claim 6 wherein said heavy chain variable region comprises SEQ ID NO:11.
8. The isolated antibody according to claim 6 wherein said light chain variable region comprises SEQ ID NO:12.
9. The isolated antibody according to claim 6 wherein said heavy chain variable region comprises SEQ ID NO:19 and said light chain variable region comprises SEQ ID NO:20.
10. The isolated antibody according to claim 6 wherein the heavy chain comprises SEQ ID NO:34 and the light chain comprises SEQ ID NO:35.
11. The isolated antibody according to claim 1 further comprising an Fc domain.
12. The isolated antibody according to claim 11 wherein said Fc domain is human.