Hydrolytically degradable polymers and hydrogels made therefrom
View Patent ↗Methods for preparing a poly(ether carbonates) of the formula HO—[(CH 2 CH 2 —O) n —CO 2 ] m —(CH 2 CH 2 —O) n —H are provided. The method comprises polymerizing an activated oligomer of the formula of H—O—(CH 2 CH 2 —O) n —CO 2 —Z, where Z is reactive leaving group.
1. A method for preparing a water-soluble, non-peptidic polymer of the formula
HO—[(CH 2 CH 2 —O) n —CO 2 ] m —(CH 2 CH 2 —O) n —H
where (n) can range from 2 to 2000 and (m) can range from 2 to 200, the method comprising polymerizing an activated oligomer of the formula of
H—O—(CH 2 CH 2 —O) n —CO 2 —Z
where (n) can range from 2 to 2000 and Z is a reactive leaving group.
2. The method of claim 1 , wherein the reactive leaving group, Z, is selected from the group consisting of N-succinimidyl, 1-benzotriazolyl, and p-nitrophenyl.
3. The method of claim 1 , wherein the reactive leaving group, Z, is N-succinimidyl.
4. The method of claim 1 , wherein the reactive leaving group, Z, is 1-benzotriazolyl.
5. The method of claim 1 , wherein the reactive leaving group, Z, is p-nitrophenyl.
6. The method of claim 1 , wherein each (n) is 5 to 500.
7. The method of claim 1 , wherein each (n) is 10 to 50.
8. The method of claim 1 , wherein (m) is 2.