IP Library › Granted Patent US 8,710,202
Granted Patent B2
US 8,710,202 · App. 13/346,042 · Granted Apr 29, 2014

Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity

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Quick Facts
Patent No.
US 8,710,202
App. No.
13/346,042
Granted
Apr 29, 2014
Kind
B2
Abstract

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.

Claims (9)

1. An isolated nucleic acid molecule encoding an antibody that specifically binds to amino acids 1-50 of the polypeptide of SEQ ID NO: 15, wherein the antibody reduces Growth and Differentiation Factor-8 (GDF-8) activity.

2. The nucleic acid molecule of claim 1 , wherein the antibody specifically binds to amino acids 1-25 of the polypeptide of SEQ ID NO: 15.

3. The nucleic acid molecule of claim 1 , wherein the antibody specifically binds to amino acids 1-15 of the polypeptide of SEQ ID NO: 15.

4. The nucleic acid molecule of claim 1 , wherein the nucleic acid molecule comprises the nucleotides of SEQ ID NO: 6.

5. An isolated nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO: 2, wherein the antibody reduces GDF-8 activity.

6. An isolated nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO: 3, wherein the antibody reduces GDF-8 activity.

7. An isolated nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO: 5, wherein the antibody reduces GDF-8 activity.

8. An isolated nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO: 8, wherein the antibody reduces GDF-8 activity.

9. An isolated nucleic acid molecule encoding an antibody having the same amino acid sequence as an antibody produced by a cell having ATCC Deposit Designation Number PTA-4236.