Closure device and method for sealing a puncture in a blood vessel

1. A method for sealing a percutaneous puncture in the wall of a blood vessel, comprising:

providing an insertion tool having an actuator which is operable in a first mode in which the actuator is configured for deployment of an inner seal inside the vessel and operable in a second mode in which the actuator is configured for tamping a locking member on an outside of the vessel, wherein the actuator is arranged to be set into said second mode in response to a pulling force acting on a filament connecting the inner seal and the locking member;

operating said insertion tool in said first mode by depressing the actuator towards a closure device housing;

pulling said filament so as to set said actuator in said second mode; and

operating said insertion tool in said second mode by depressing the actuator towards the closure device housing.

2. The method of claim 1 , wherein the step of operating the insertion tool in said first mode disables operation of the insertion tool in said second mode, until the step of pulling said filament sets the actuator into said second mode.

3. A closure device, comprising:

an actuator movable between an initial extended position, a first position, and a second position with respect to a housing of the closure device;

an inner seal configured to deploy from a distal end of the closure device when the actuator shifts from the initial extended position to the first position;

a biasing mechanism configured to urge the actuator from the first position to the second position when a pulling force is applied to the housing; and

a locking member configured to move into a locking position;

wherein the actuator is configured such that movement of the actuator from the second position towards the housing of the closure device causes a substantially simultaneous movement of the locking member into the locking position.

4. The closure device of claim 3 , wherein a proximal end portion of the actuator abuts a proximal end of the housing in the first position.

5. The closure device of claim 3 , further comprising a latch mechanism to temporarily retain the actuator in the first position subsequent to deployment of the inner seal.

6. The closure device of claim 5 , wherein the closure device is configured such that application of the pulling force, subsequent to deployment of the inner seal, releases the latch mechanism to enable the actuator to shift from the first position to the second position prior to deployment of the locking member.

7. The closure device of claim 3 , further comprising a filament to connect the inner seal and the locking member.

8. The closure device of claim 3 , further comprising a push rod detachably connected to the inner seal and a tamping rod configured to advance the locking member.

9. A closure device for sealing a blood vessel, comprising:

an inner seal configured to deploy from the closure device into the blood vessel;

a locking member configured to deploy from the closure device to abut an outer surface of the blood vessel;

a filament to connect the inner seal and the locking member;

a latch mechanism configured to maintain an actuator stationary in a first position relative to a housing of the closure device without force from a user;

wherein the closure device is configured such that application of a pulling force to the filament, subsequent to deployment of the inner seal, releases the latch mechanism to shift the actuator of the closure device from the first position to a second position relative to the housing of the closure device and to enable deployment of the locking member.

10. The closure device of claim 9 , wherein the actuator is configured to shift from an initial extended position to the first position to deploy the inner seal.

11. The closure device of claim 9 , wherein the actuator is configured to shift from the second position to the first position to deploy the locking member.

12. The closure device of claim 9 , further comprising a slide member engaged with the filament such that application of the pulling force to the filament displaces the slide member with respect to the actuator.

13. The closure device of claim 9 , further comprising a push rod detachably connected to the inner seal and a tamping rod configured to advance the locking member.

14. The closure device of claim 9 , wherein the housing includes a first passage configured to hold the inner seal and locking member and a second passage configured to receive a guide rod.

15. A closure device, comprising:

an actuator movable between an initial extended position, a first position, and a second position with respect to a housing of the closure device;

an inner member configured to deploy from a distal end of the closure device when the actuator shifts from the initial extended position to the first position;

a biasing mechanism configured to urge the actuator from the first position to the second position when a pulling force is applied to the housing; and

a second member configured to deploy from the distal end of the closure device;

wherein the actuator is configured such that movement of the actuator from the second position towards the housing of the closure device causes a substantially simultaneous deployment of the second member from the distal end of the closure device.