Evacuating a sample chamber

1. A method of transferring a sample into a mass spectrometer, the method comprising:

capturing a surface-wiped sample on a collector;

receiving, by a sample chamber, the collector carrying the surface-wiped sample, wherein the sample chamber includes two mechanically coupled portions to allow insertion or removal of the collector by at least partially separating the two portions;

forming, through operation of the two portions, a substantially air-tight cavity within the sample chamber, the cavity containing the collector;

isolating the sample chamber from the mass spectrometer;

evacuating the isolated sample chamber using a vacuum pump to reduce an internal pressure of the sample chamber to a level substantially less than atmospheric pressure to increase an effective concentration of the sample;

heating the collector to release the sample from the collector; and

introducing the sample into the mass spectrometer from the evacuated sample chamber.

2. The method of claim 1 , wherein the collector comprises a sorbent material.

3. The method of claim 1 , wherein capturing the sample on the collector comprises wiping a surface of a target object with the collector.

4. The method of claim 1 , wherein the collector is pressed against a heating element in the sample chamber.

5. The method of claim 1 , wherein heating the collector comprises conducting current through a heating element to induce Joule heating.

6. The method of claim 5 , further comprising determining a temperature of the collector based on a measured resistance of the heating element.

7. The method of claim 1 , wherein heating the collector comprises conducting current through the collector to induce Joule heating.

8. The method of claim 1 , wherein heating the collector comprises emitting radiant energy substantially toward the collector using one or more heating elements.

9. The method of claim 8 , wherein heating the collector comprises reflecting the emitted radiant energy substantially toward the collector using a reflective barrier.

10. The method of claim 1 , wherein the sample includes a first compound and a second compound different from the first compound, and wherein heating the collector comprises heating the collector to a first temperature during a first time period and a second temperature during a second time period, and wherein release of the first compound is initiated during the first time period, and release of the second compound is initiated during the second time period.

11. The method of claim 10 , wherein heating the collector comprises operating a resistive heating element or a radiant heating element at a first power level during the first time period and at a second power level during the second time period.

12. The method of claim 10 , wherein heating the collector comprises emitting radiant energy having a first radiant frequency substantially toward the collector during the first time period, and emitting radiant energy having a second radiant frequency substantially toward the collector during the second time period.

13. The method of claim 1 , wherein the sample includes a first compound and a second compound, different from the first compound, and wherein evacuating the sample chamber using the vacuum pump to reduce the internal pressure of the sample chamber comprises:

reducing the internal pressure of the sample chamber to a first level during a first time period; and

reducing the internal pressure of the sample chamber to a second level during a second time period,

wherein in response to heating the collector, release of the first compound is initiated during the first time period and release of the second compound is initiated during the second time period.

14. The method of claim 1 , wherein the sample includes a first compound and a second compound, different from the first compound, and wherein introducing the sample into the mass spectrometer from the evacuated sample chamber comprises introducing the first compound during a first time period and introducing the second compound during a second time period.

15. A sample analysis system comprising:

a sample chamber configured to receive a collector carrying a surface-wiped sample, the sample chamber comprising a base and a lid mechanically coupled to each other and operable to at least partially separate from each other to allow insertion or removal of the collector, wherein the base and the lid are configured to form a substantially air-tight cavity that contains the collector within the sample chamber;

a chemical analyzer coupled to the sample chamber;

a valve configured to isolate the cavity from the chemical analyzer;

a vacuum pump coupled to the sample chamber and configured to evacuate the sample chamber to reduce an internal pressure of the sample chamber to a level substantially less than atmospheric pressure to increase an effective concentration of the sample in the cavity after the cavity is isolated from the chemical analyzer by the valve; and

a heating element configured to heat the collector to release the sample from the collector into the evacuated sample chamber,

wherein the chemical analyzer is configured to receive the sample from the evacuated sample chamber.

16. The system of claim 15 , wherein the collector comprises a sorbent material.

17. The system of claim 15 , wherein the collector is a wipe.

18. The system of claim 15 , wherein the collector is a substrate.

19. The system of claim 15 , wherein the collector is a swab.

20. The system of claim 15 , wherein the base and lid are configured to press the collector against the heating element.

21. The system of claim 15 , wherein the heating element is configured to generate heat via Joule heating.

22. The system of claim 15 , wherein the heating element is configured to emit radiant energy substantially toward the collector.

23. The system of claim 22 , wherein the emitted radiant energy is of a particular wavelength that preferentially excites a sample of interest.

24. The system of claim 22 , further comprising a reflective barrier configured to reflect the emitted radiant energy substantially toward the collector.

25. The system of claim 15 , wherein the sample includes a first compound and a second compound different from the first compound, and wherein the heating element is configured to heat the collector to a first temperature during a first time period and a second temperature during a second time period, and wherein release of the first compound is initiated during the first time period, and release of the second compound is initiated during the second time period.

26. The system of claim 25 , wherein the heating element is configured to operate at a first power level during the first time period and at a second power level during the second time period.

27. The system of claim 25 , wherein the heating element is configured to emit radiant energy having a first radiant frequency substantially toward the collector during the first time period, and is configured to emit radiant energy having a second radiant frequency substantially toward the collector during the second time period.

28. The system of claim 15 , wherein the sample includes a first compound and a second compound, different from the first compound, and wherein the vacuum pump is configured to reduce the internal pressure of the sample chamber to a first level during a first time period, and to reduce the internal pressure of the sample chamber to a second level during a second time period, wherein in response to heating of the collector, release of the first compound is initiated during the first time period and release of the second compound is initiated during the second time period.

29. A device for transferring a surface-wiped sample into a chemical analyzer, comprising:

a base and a lid forming a sample chamber configured to receive a collector carrying the surface-wiped sample, the base and the lid being mechanically coupled to each other and operable to at least partially separate from each other to allow insertion or removal of the collector, wherein the base and the lid are configured to form a substantially air-tight cavity that contains the collector within the sample chamber;

a vacuum port coupled to a valve configured to isolate the sample chamber from the chemical analyzer; and

a heating or radiating element configured to heat the collector to release the sample from the collector,

wherein the device is configured to be coupled to a vacuum pump through the vacuum port, the vacuum pump being operable to evacuate the device to reduce an internal pressure of the device to a level substantially less than atmospheric pressure to increase an effective concentration of the sample in the sample chamber.