Alkylsulfonyl-substituted thiazolide compounds
View Patent ↗A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.
1. A compound having a formula (I)
wherein one of R 6 or R 9 is C 1 -C 6 alkylsulfonyl, and the other is hydrogen,
or a pharmaceutically acceptable salt or ester thereof.
2. A compound according to claim 1 , selected from the group consisting of structures:
3. A compound according to claim 1 , selected from the group consisting of:
4. The compound of claim 1 , wherein R 6 or R 9 is SO 2 CH 3 and the other R 6 or R 9 is H.
5. The compound of claim 1 , wherein the compound of formula (I) is the pharmaceutically acceptable ester.
6. The compound of claim 5 , wherein the pharmaceutically acceptable ester is a (C 1 -C 6 )-acyloxy.
7. The compound of claim 1 , wherein the compound is the pharmaceutically acceptable salt.
8. The compound of claim 7 , wherein the pharmaceutically acceptable salt is selected from the group consisting of acetate, adipate, alginate, aspartate, benzoate, benzenesulfonate, bisulfate butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycero-phosphate, hemisulfate, heptanoate, hexanoate, hydrochloride hydrobromide, hydroiodide, 2-hydroxyethane-sulfonate, lactate, maleate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, oxalate, thiocyanate, tosylate and undecanoate.
9. The compound of claim 4 , wherein the compound of formula (I) is the pharmaceutically acceptable ester.
10. The compound of claim 9 , wherein the pharmaceutically acceptable ester is a (C 1 -C 6 )-acyloxy.
11. A pharmaceutical composition comprising a compound of claim 1 and a carrier.
12. A pharmaceutical composition comprising a compound of claim 2 and a carrier.
13. A pharmaceutical composition comprising a compound of claim 3 and a carrier.
14. A pharmaceutical composition comprising a compound of claim 4 and a carrier.
15. A pharmaceutical composition comprising a compound of claim 5 and a carrier.
16. A pharmaceutical composition comprising a compound of claim 6 and a carrier.
17. A pharmaceutical composition comprising a compound of claim 7 and a carrier.
18. A pharmaceutical composition comprising a compound of claim 8 and a carrier.
19. A pharmaceutical composition comprising a compound of claim 9 and a carrier.
20. A pharmaceutical composition comprising a compound of claim 10 and a carrier.