IP Library Granted Patent US 8,439,666
Granted Patent B2
US 8,439,666 · App. 13/354,046 · Granted May 14, 2013

Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom

Inventors: Jason P. Rolland (Belmont, MA); Benjamin Maynor (Durham, NC); Robert Lyon Henn (Raleigh, NC)
Assignee: Liquidia Technologies, Inc.
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Quick Facts
Patent No.
US 8,439,666
App. No.
13/354,046
Granted
May 14, 2013
Kind
B2
Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

Claims (24)

1. A laminate mold comprising:

a mold layer including a first surface defining a plurality of cavities, wherein each cavity of the plurality of cavities has a predetermined shape and is less than 10 micrometers in a largest dimension, the mold layer having a thickness of less than 75 micrometers and comprising a cured polymer material selected from the group consisting of: fluoropolyether, perfluoropolyether, poly(dimethylsiloxane), poly(tetramethylene oxide), poly(ethylene oxide), poly(oxetanes), polyisoprene, polybutadiene, and fluoroolefin-based fluoroelastomers; and

a support layer affixed to a second surface of the mold layer opposite the first surface;

wherein the laminate mold has a modulus of greater than 1000 MPa.

2. The laminate mold of claim 1 , wherein the support layer is affixed to the mold layer by a tie-layer disposed between the support layer and the second surface of the mold layer.

3. The laminate mold of claim 2 , wherein the tie-layer comprises a dual-cured material.

4. The laminate mold of claim 2 , wherein the tie-layer comprises a photocured component and a thermally cured component.

5. The laminate mold of claim 2 , wherein the tie-layer has a thickness between 5 micrometers and 75 micrometers.

6. The laminate mold of claim 1 , wherein the support layer has a thickness of less than 10 mil.

7. The laminate mold of claim 1 , wherein the support layer comprises a polymer material.

8. The laminate mold of claim 1 , wherein the support layer comprises poly(ethylene terephthalate).

9. The laminate mold of claim 1 , wherein each cavity of the plurality of cavities is less than 5 micrometers from an adjacent cavity.

10. The laminate mold of claim 1 , wherein the cured polymer material has a surface energy between 7 mN/m and 20 mN/m.

11. The laminate mold of claim 1 , wherein the laminate mold has a modulus of at least 1400 MPa.

12. The laminate mold of claim 1 , wherein the cured polymer material comprises an elastomer.

13. The laminate mold of claim 1 , wherein each cavity of the plurality of cavities is less than 1 micrometer in a largest dimension.

14. A laminate mold comprising:

a mold layer including a first surface defining a plurality of cavities, wherein each cavity of the plurality of cavities has a predetermined shape and is less than 10 micrometers in a largest dimension, the mold layer having a thickness of less than 75 micrometers and comprising an elastomer having a surface energy of less than 30 mN/m and selected from the group consisting of: fluoropolyether, perfluoropolyether, poly(dimethylsiloxane), poly(tetramethylene oxide), poly(ethylene oxide), poly(oxetanes), polyisoprene, polybutadiene, and fluoroolefin-based fluoroelastomers; and

a polymer support layer affixed to a second surface of the mold layer opposite the first surface by a tie-layer comprising a dual-cured material disposed between the polymer support layer and the second surface of the mold layer;

wherein the laminate mold has a modulus of greater than 1000 MPa.

15. The laminate mold of claim 14 , wherein the polymer support layer comprises poly(ethylene terephthalate).

16. The laminate mold of claim 14 , wherein the tie-layer comprises a photocured component and a thermally cured component.

17. The laminate mold of claim 14 , wherein the elastomer has a surface energy between 7 mN/m and 20 mN/m.

18. The laminate mold of claim 14 , wherein each cavity of the plurality of cavities is less than 1 micrometer in a largest dimension.

Assignments (3)
ASSIGNMENT OF IP SECURITY AGREEMENT RECORDED AT REEL/FRAME 062643/0791 Recorded May 11, 2023
From: HCR COLLATERAL MANAGEMENT, LLC, AS RETIRING SUBORDINATED LENDER
To: HEALTHCARE ROYALTY PARTNERS IV, L.P., AS SUCCESSOR SUBORDINATED LENDER
Reel/Frame 063627/0307 →
SECURITY INTEREST Recorded Feb 9, 2023
From: LIQUIDIA TECHNOLOGIES, INC.
To: HCR COLLATERAL MANAGEMENT, LLC
Reel/Frame 062643/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 19, 2013
From: ROLLAND, JASON P.; MAYNOR, BENJAMIN W.; HENN, ROBERT L.
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 030643/0414 →
Continuity (2)
Continuation 11633763 · Dec 4, 2006
Related Publication 20120189728A1 · Jul 26, 2012