The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
1. A composition comprising an immunostimulatory effective amount of aluminum salt adjuvant and a purified polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO: 2536, wherein the fragment comprises 18 or more consecutive amino acids from the amino acid sequence, and wherein the purified polypeptide is immunogenic.
2. The composition of claim 1 comprising the fragment, wherein the fragment comprises 20 or more consecutive amino acids from the amino acid sequence of SEQ ID NO: 2536.
3. The composition of claim 1 , in combination with a pharmaceutically acceptable carrier.
4. The composition of claim 2 , in combination with a pharmaceutically acceptable carrier.
5. The composition of claim 1 , in further combination with a pH buffering agent.
6. The composition of claim 2 , in further combination with a pH buffering agent.
7. The composition of claim 1 , wherein the composition is formulated as an injectable.
8. The composition of claim 1 , wherein the purified polypeptide is recombinant.
9. The composition of claim 1 , wherein the aluminum salt adjuvant comprises an aluminum hydroxide adjuvant.
10. The composition of claim 1 , wherein the aluminum salt adjuvant comprises an aluminum phosphate adjuvant.