Co-enzyme Q10 formulations and methods of use
Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.
1. A method of treating a solid tumor in a subject comprising intravenously administering to the subject having a solid tumor a composition comprising 1% to 20% w/w of Coenzyme Q10 in an amount effective and for a sufficient time to slow the growth of the solid tumor, thereby treating the solid tumor in the subject.
2. The method of claim 1 , wherein the composition comprises 1% to 10% w/w of Coenzyme Q10.
3. The method of claim 1 , wherein the composition comprises 1% to 5% w/w of Coenzyme Q10.
4. The method of claim 1 , wherein the Coenzyme Q10 composition is administered with an additional anti-cancer agent.
5. The method of claim 1 , comprising intravenously administering Coenzyme Q10 by continuous infusion.
6. The method of claim 1 , wherein the subject has a tumor prior to first administration to the subject of the composition comprising Coenzyme Q10.
7. The method of claim 6 , wherein the additional anti-cancer agent is co-administered with the composition comprising Coenzyme Q10 to the subject.
8. The method of claim 6 , wherein administration of the additional anti-cancer agent precedes administration of the composition comprising Coenzyme Q10 to the subject.
9. The method of claim 6 , wherein administration of the additional anti-cancer agent follows administration of the composition comprising Coenzyme Q10 to the subject.
10. The method of claim 6 , wherein the additional anti-cancer agent is an anti-angiogenic agent.
11. The method of claim 6 , wherein the additional anti-cancer agent is a chemotherapeutic agent.
12. The method of claim 11 , wherein the chemotherapeutic agent is selected from the group consisting of cyclophosphamide, taxanes, busulfan, methotrexate, daunorubicin, doxorubicin, melphalan, cladribine, vincristine, vinblastine, chlorambucil, tamoxifen, taxol, camptothecin, actinomycin-D, mitomycin C, combretastatin, cisplatin, etoposide, verapamil, podophyllotoxin, and 5-fluorouracil.
13. The method of claim 12 , wherein the taxane is paclitaxel or docetaxel.
14. The method of claim 1 , wherein the solid tumor is a pancreatic tumor.
15. The method of claim 1 , wherein the solid tumor is a breast tumor.
16. The method of claim 1 , wherein the solid tumor is a lung tumor.
17. The method of claim 1 , wherein the solid tumor is a liver tumor.
18. The method of claim 1 , wherein the solid tumor is a colon tumor.
19. The method of any one of claims 2 - 3 , 4 , 5 - 13 and 15 - 18 , wherein the subject is a human subject.