Ophthalmic compositions containing diglycine

1. An ophthalmic composition comprising:

0.05% w/v to 2% w/v diglycine or a salt thereof;

1.0 ppm to 8.5 ppm alexidine; and

0.1% w/v to 2% w/v of one or more boron buffering compounds.

2. The composition of claim 1 further comprising hyaluronic acid or a salt thereof.

3. The ophthalmic composition of claim 1 further comprising a sulphobetaine surfactant of the formula

wherein R 1 and R 2 are independently selected from a C 1 -C 4 alkyl;

A is an unsubstituted or a substituted alkylene with two to four carbons, and m is an integer from 2 to 4;

Y is a straight or branched alkyl, or a straight or branched alkene, with eight to sixteen carbons; and

Z is —SO 3 − or —CO 2 − , preferably Z is —SO 3 − .

4. The composition of claim 1 further comprising dexpanthenol, sorbitol, propylene glycol, aspartic acid, glycolic acid, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

5. The composition of claim 1 further comprising hydroxypropylmethyl cellulose.

6. The composition of claim 1 further comprising a disuccinate of formula

or a corresponding salt thereof; wherein R 1 is selected from hydrogen, alkyl or —C(O)alkyl, the alkyl having one to twelve carbons and optionally having one or more oxygen atoms; and

A is a methylene group or an oxyalkylene group, and n is from 2 to 10.

7. The composition of claim 1 wherein the one or more boron buffering compounds include boric acid from 0.15% w/v to 0.6% w/v, sodium or potassium borate from 0.05% w/v to 0.5% w/v, and the diglycine from 0.1% w/v to 0.7% w/v.

8. An ophthalmic composition comprising:

buffering compounds including boric acid from 0.15% w/v to 0.6% w/v, sodium or potassium borate from 0.05% w/v to 0.5% w/v, and diglycine from 0.1% w/v to 0.7% w/v;

1.0 ppm to 8.5 ppm alexidine; and

hyaluronic acid or a salt thereof, which is present from 0.05 wt. % to 0.2 wt. %.

9. The composition of claim 8 further comprising 1 ppm to 10 ppm of α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride.

10. The composition of claim 8 further comprising a disuccinate of formula

or a corresponding salt thereof; wherein R 1 is selected from hydrogen, alkyl or —C(O)alkyl, the alkyl having one to twelve carbons and optionally having one or more oxygen atoms; and

A is a methylene group or an oxyalkylene group, and n is from 2 to 10.

11. A method to disinfect contact lenses comprising contacting or soaking the contact lenses with an aqueous ophthalmic composition for a minimum of one to four hours, and repositioning the lenses on the eye, wherein the composition comprises:

0.05% w/v to 2% w/v diglycine or a salt thereof;

1.0 ppm to 8.5 ppm alexidine; and

0.1% w/v to 2% w/v of one or more boron buffering compounds.

12. The method of claim 11 wherein the composition further comprises 1 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride.