Stable polyphenol containing ophthalmic emulsion for treating dry eyes
View Patent ↗Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A or polyphenol in an amount effective to relieve dry eye symptoms.
1. A stable oil-in-water emulsion ophthalmic topical liquid composition having an average particle size less than 0.6 μm, consisting essentially of:
jojoba oil;
a polyethylene glycol ester having a HLB of about 10;
a polyoxyethylene oleyl ether with a HLB of about 4.9; and
curcumin or white curcumin, in an amount effective to relieve dry eye symptoms.