Active metabolite of a thrombin receptor antagonist
View Patent ↗Disclosed herein is an active metabolite (“M20”) of a molecule that is useful as a thrombin receptor antagonist: Also disclosed are formulations of this compound, synthetic routes to this compound, and methods of treating a variety of cardiovascular conditions, including acute coronary syndrome and peripheral arterial disease, and of effecting secondary prevention, by orally administering the active metabolilte.
1. A compound of the following formula:
or a pharmaceutically acceptable salt or hydrate thereof in an isolated or purified form.
2. The free base of the compound according to claim 1 .
3. A pharmaceutically acceptable salt of the compound according to claim 1 .
4. A hydrate form of the compound according to claim 1 .
5. A pharmaceutical composition comprising an effective amount of a compound of the formula
or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier.
6. The pharmaceutical composition according to claim 5 , which further comprises one or more additional cardiovascular agents.
7. The pharmaceutical composition according to claim 6 , wherein said cardiovascular agent is aspirin, clopidogrel, prasugrel, or the pharmaceutically acceptable salts hydrates of said agents.