CATION COMPATIBLE METAL OXIDES AND ORAL CARE COMPOSITIONS CONTAINING THE METAL OXIDES
A cationic compatible metal oxide and oral care compositions containing the metal oxide are disclosed. Preferably, the oral care compositions contain a cationic compatable metal oxide and a cationic ingredient, such as for example, a cationic antibacterial agent such as cetyl pyridinium chloride (“CPC”). The cationic compatible metal oxide, e.g. silica, comprise metal oxide particles having a subtantially negative surface charge and a vitamin deposited onto or reacted with the surface of the metal oxide particles in an amount sufficient to provide a substantially positive surface charge on the metal oxide particle. Processes for making and using the vitamin modified metal oxide in oral care compositions are also disclosed.
1 . A cationic compatible metal oxide which comprises a metal oxide particle having a negative surface charge and a vitamin molecule immobilized on the surface of the metal oxide particle in an amount sufficient to provide a substantially positive charge on the surface of the metal oxide particle.
2 . The cationic compatible metal oxide of claim 1 wherein the metal oxide of the metal oxide particle has an isoelectric point of less than 7.
3 . The cationic compatible metal oxide of claim 2 wherein the metal oxide is selected from the group consisting of silicia, titania, zirconia, silica alumina and mixtures thereof.
4 . The cationic compatible metal oxide of claim 1 , wherein the vitamin molecule is immobilized directly onto the surface of the metal oxide particle.
5 . The cationic compatible metal oxide of claim 1 , wherein the amount of vitamin molecule immobilized on the surface of the metal oxide particle ranges from about 0.01 to about 10.0 wt % of the metal oxide.
6 . The cationic compatible metal oxide of claim 1 wherein the vitamin molecule is selected from the group consisting of vitamin B, vitamin M, vitamin U, their salts and derivatives, and mixtures thereof.
7 . The cationic compatible metal oxide of claim 6 wherein the vitamin molecule is a vitamin B.
8 . The cationic compatible metal oxide of claim 7 wherein the vitamin B is selected from the group consisting of vitamin B1, vitamin B2, vitamin B6, their salts thereof, and mixtures thereof.
9 . The cationic compatible metal oxide of claim 4 wherein the vitamin molecule is impregnated directly onto the surface of the metal oxide particle.
10 . The cationic compatible metal oxide of claim 4 wherein the vitamin molecule is adsorbed directly onto the surface of the metal oxide particle.
11 . The cationic compatible metal oxide of claim 4 wherein the vitamin molecule is chemically reacted directly with the surface of the metal oxide particle.
12 . The cationic compatible metal oxide of claim 1 , 5 or 8 wherein the metal oxide particle is a silica particle.
13 . An oral care composition comprising
(1) an antibacterial effective amount of at least one cationic antibacterial agent; and
(2) at least one metal oxide particle having a isoelectric point of less than 7 and having at least one vitamin molecule immobilized on the surface of the metal oxide particle in an amount sufficient to repel or minimize the reaction of the metal oxide with said at least one cationic antibacterial agent.
14 . The oral care composition of claim 13 wherein the cationic antibacterial agent is cetylpridinium chloride (CPC).
15 . The oral care composition of claim 13 wherein the metal oxide of the metal oxide particle is selected from the group consisting of silica, titania, zirconia, silica alumina and mixtures thereof.
16 . The oral care composition of claim 13 wherein the amount of vitamin molecule immobilized on the surface of the metal oxide particle ranges from about 0.01 wt % to about 10.0 wt % of the metal oxide.
17 . The oral care composition of claim 16 , wherein the vitamin molecule is immobilized directly onto the surface of the metal oxide particle.
18 . The oral care composition of claim 13 , wherein the vitamin molecule is selected from the group consisting of vitamin B, vitamin M, vitamin U, their salts and derivatives, and mixtures thereof.
19 . The oral care composition of claim 18 wherein the vitamin molecule is a vitamin B.
20 . The oral care composition of claim 19 wherein the vitamin B is selected from the group consisting of vitamin B1, vitamin B2, vitamin B6, salts thereof, and mixtures thereof.
21 . The oral care composition of claim 20 wherein the metal oxide of the metal oxide particle is silica.
22 . The oral care composition of claim 17 wherein the vitamin molecule is impregnated onto the surface of the metal oxide particle.
23 . The oral care composition of claim 17 wherein the vitamin molecule is adsorbed directly onto the surface of the metal oxide particle.
24 . The oral care composition of claim 17 wherein the vitamin molecule is chemically reacted with the surface of the metal oxide particle.
25 . The oral care composition of claim 13 wherein the composition is in the form selected from dentrifices, chewing gums, mouthwashes and mixtures thereof.
26 . The oral care composition of claim 25 wherein the composition is a dentrifice selected from the group consisting of toothpastes, tooth powders, denture creams and mixtures thereof.
27 . The oral care composition of claim 13 further comprising at least one material selected from the group consisting of thickening agents, whiteners, abrasive agents, flavorants, humectants, detergents, surfactants, fluoride supplying compounds, desensitizing agents and mixtures thereof.
28 . The oral care composition of claim 13 further comprising at least one sweetening agent.
29 . The oral care composition of claim 13 further comprising at least one additional cationic antibacterial agent.
30 . A method of reducing the presence of microorganisms in an oral cavity of a warm-blooded animal, said method comprising administering to the oral cavity of a warm-blooded animal an effective amount of an oral care composition of claims 13 , 14 , 15 and 20 .
31 . The method of claim 30 wherein the warm blooded animal is a human.
32 . The method of claim 30 wherein the oral care composition is in the form selected from dentrifices, chewing gums, mouthwashes and mixtures thereof.
33 . The method of claim 32 wherein the oral care composition is a dentrifice selected from the group consisting of toothpastes, tooth powders, denture creams and mixtures thereof.
34 . The method of claim 30 wherein the oral care composition further comprises at least one material selected from the group consisting of thickening agents, whiteners, abrasive agents, flavorants, humectants, detergents, surfactants, fluoride supplying compounds, desensitizing agents, sweetening agent, and mixtures thereof.
35 . The method of claim 30 wherein the oral care composition further comprising at least one additional cationic antibacterial agent.
36 . The cationic compatible metal oxide of claim 12 wherein the silica particle has a % CPC compatability of at least 10%.