Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
View Patent ↗The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination therapy for treatment of an angiogenesis related condition. In an embodiment, the invention provides a class of opioid compounds and structurally related opioid derivatives exhibiting anti-VEGF activity for use in therapeutic procedures, including phototherapy. Opioid compounds and structurally related opioid derivatives of the invention may be administered alone or in combination with administration of a phototherapy agent and/or other therapeutic agent.
1. A method for treating cancer, the method comprising;
administering to a patient in need of treatment an effective amount of a purified (+) enantiomer compound substantially free of a corresponding (−) enantiomer; the (+) enantiomer compound having any of the formula:
2. The method of claim 1 comprising a method for treating pancreatic cancer.
3. The method of claim 1 comprising a method of suppressing tumor growth or tumor metastasis.
4. The method of claim 1 , further comprising administering to said patient one or more chemotherapeutic agents.
5. The method of claim 1 , further comprising administering to said patient one or more VEGF inhibitors.
6. The method of claim 1 , further comprising administering to said patient 5-fluorouracil, floxuridine, furtulon, capecitabine, gemcitabine, taxol, doxorubicin, cisplatin, thalidomide, paclitaxel, docetaxel or bevacizumab.
7. The method of claim 1 , further comprising administering to said patient gemcitabine or bevacizumab.
8. A method for treating cancer, the method comprising:
administering to a patient in need of treatment an effective amount of a purified (+) enantiomer compound substantially free of a corresponding (−) enantiomer, the (+) enantiomer compound having the formula (FX79) or (FX80):
9. The method of claim 8 comprising a method for treating pancreatic cancer.
10. The method of claim 8 comprising a method of suppressing tumor growth or tumor metastasis.
11. The method of claim 8 , further comprising administering to said patient one or more chemotherapeutic agents.
12. The method of claim 8 , further comprising administering to said patient one or more VEGF inhibitors.
13. The method of claim 8 , further comprising administering to said patient 5-fluorouracil, floxuridine, furtulon, capecitabine, gemcitabine, taxol, doxorubicin, cisplatin, thalidomide, paclitaxel, docetaxel or bevacizumab.
14. The method of claim 8 , further comprising administering to said patient gemcitabine or bevacizumab.