Topical pharmaceutical composition including rel-N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4′-(trifluoromethoxY)-[1,1′-biphenyl]-3-carboxamide
View Patent ↗The present invention relates to pharmaceutical compositions of 2-Methyl-4′-trifluoromethoxy-biphenyl-3-carboxylic acid [6-(cis-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-amide, to the use of such compositions in therapeutic applications and to methods for manufacturing such compositions.
1. A crystalline polymorph Form A of 2-methyl-4′-trifluoromethoxy-biphenyl-3-carboxylic acid [6-(cis-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-amide that exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at 12.9, 16.5, 17.0, 18.6, 19.9, 21.2, 22.4, 24.3, 25.8 and 26.1.
2. The crystalline polymorph Form A of claim 1 as characterized by the X-ray powder diffraction pattern of FIG. 3 .
3. A pharmaceutical composition comprising the crystalline polymorph Form A according to claim 1 and an excipient.