Granted Patent
B2
US 9,102,959 · App. 13/390,677 · Granted Aug 11, 2015
Ketoreductase polypeptides for the preparation of phenylephrine
Inventors:
Oscar Alvizo (Fremont, CA); Steven J. Collier (Singapore, SG); Joerg Hennemann (Bedburg, DE); Seong Ho Oh (Singapore, SG); Wenjuan Zha (Singapore, SG)
Assignee:
Codexis, Inc.
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Abstract
The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
Claims (2)
1. An engineered polypeptide comprising the polypeptide of SEQ ID NO:6, wherein the engineered polypeptide is capable of converting 1-(3-hydroxyphenyl)-2-(methylamino) ethanone to (R)-phenylephrine.
2. The engineered polypeptide of claim 1 , wherein the polypeptide is capable of stereospecifically converting 1-(3-hydroxyphenyl)-2-(methylamino)ethanone to (R)-phenylephrine in a enantiomeric excess of at least 99%.
Assignments (2)
SECURITY INTEREST
Recorded Feb 15, 2024
From: CODEXIS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 066600/0650 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 1, 2012
From: ALVIZO, OSCAR; COLLIER, STEVEN J.; HENNEMANN, JOERG; OH, SEONG HO; ZHA, WENJUAN
To: CODEXIS, INC.
Reel/Frame 028137/0285 →
Continuity (2)
Provisional Application
61235324
· Aug 19, 2009