Cysteine for physiological injection
This application describes methods of making and using physiological cysteine solutions useful for reversing a neuromuscular blockade caused by a cysteine-reversible neuromuscular blockade agent, that overcomes problems of cysteine precipitation and dimerization.
1. A method of reversing a neuromuscular blockade in a patient to whom a cysteine-reversible neuromuscular blockade agent has been administered, comprising administering an effective amount of a physiological solution comprising D-cysteine substantially free of L-cysteine to the patient.
2. A method of reversing a neuromuscular blockade in a patient to whom a cysteine-reversible neuromuscular blockade agent has been administered, comprising administering an effective amount of a physiological solution of cysteine substantially free of L-cysteine to the patient, wherein the physiological solution of cysteine has been made by a method comprising:
adding NaOH and/or a buffering solution to cysteine HCl to generate a 150-250 mg/ml cysteine solution,
wherein the solution is a physiological solution in a volume suitable for intravenous administration over a period of time of about 2 seconds to about 60 seconds.
3. The method of claim 2 , wherein oxygen has been substantially removed from the NaOH or buffering solution.
4. A method of making a cysteine solution for physiological administration, where the method involves:
adding NaOH and/or a buffering solution to cysteine HCl to generate a 150-250 mg/ml cysteine solution,
wherein the solution is a physiological solution in a volume suitable for intravenous administration over a period of time of about 2 seconds to about 60 seconds.
5. The method of claim 2 , wherein the cysteine is D-cysteine.
6. The method of claim 1 , wherein the cysteine is D-cysteine.