Implantable bio-resorbable polymer

1. A polymer obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —CH 3 , (CH 2 —CH 2 —O) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 ═(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio-resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 ═CH 2 ).

2. The polymer according to claim 1 , which is in the form of a film, a foam, a particle, in particular a spherical particle, a lump, a thread, or a sponge.

3. A pharmaceutical composition comprising at least one polymer in association with a pharmaceutically acceptable carrier, wherein the polymer is obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —CH 3 , (CH 2 —CH 2 —O ) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 =(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

 polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof,. wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio-resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 ═CH 2 ).

4. An implant comprising a pharmaceutical composition comprising at least one polymer in association with a pharmaceutically acceptable carrier, wherein the polymer is obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —CH 3 , (CH 2 —CH 2 —O) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 ═(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

 polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio-resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 ═CH 2 ).

5. An injectable pharmaceutical comprising a pharmaceutical composition comprising at least one polymer in association with a pharmaceutically acceptable carrier, wherein the polymer is obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —CH 3 , (CH 2 —CH 2 —O) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 ═(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

 polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio- resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 ═CH 2 ).

6. The implant of claim 4 suitable for implantation into tissues, internal anatomical spaces, body cavities, ducts and vessels.

7. A method for treating a condition selected from the group consisting of inflammation and cancer comprising administering a therapeutically effective amount of a pharmaceutical composition to a patient in need of treatment, wherein the pharmaceutical composition comprises at least one polymer in association with a pharmaceutically acceptable carrier, wherein the polymer is obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —CH 3 , (CH 2 —CH 2 —O) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1 -C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 =(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

 polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio- resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 ═CH 2 ).

8. The pharmaceutical composition according to claim 3 , wherein the at least one polymer is in association with a drug or a prodrug.

9. A method for implanting a pharmaceutical composition to a patient in need thereof, comprising implanting an effective amount of the pharmaceutical composition into said patient at a location selected from tissues, internal anatomical spaces, body cavities, ducts and vessels, wherein the pharmaceutical composition comprises at least one polymer in association with a pharmaceutically acceptable carrier, wherein the polymer is obtained from the polymerization of:

(i) at least one monomer of formula (I)

(CH 2 ═CR 1 )CO—K  (I)

 wherein:

—K represents O—Z or NH—Z, Z representing (CR 2 R 3 ) m —Ch 3 , (CH 2 —CH 2 —O ) m —H, (CH 2 —CH 2 —O) m —CH 3 , (CH 2 ) m —NR 4 R 5 with m representing an integer from 1 to 30;

—R 1 , R 2 , R 3 , R 4 and R 5 independently represent H or a C1-C6 alkyl; and

(ii) at least one bio-resorbable block copolymer cross-linker, wherein the bio-resorbable block copolymer cross-linker is linear and presents (CH 2 ═(CR 6 ))— groups at both extremities, wherein R 6 independently represents H or a C1-C6 alkyl, and wherein the block of the bio-resorbable block copolymer cross-linker is selected from the group consisting of:

 polyethylene glycol (PEG), poly-lactic acid (PLA), poly-glycolic acid (PGA) and poly-lactic-glycolic acid (PLGA), and combinations thereof, wherein the monomer is poly(ethylene glycol) methyl ether methacrylate and wherein the bio-resorbable block copolymer cross-linker is (CH 2 ═CCH 3 )CO-PLGA-PEG-PLGA-CO(CCH 3 =CH 2 ).