Granulated material mixture comprising two different granulated materials for artificial callus distraction
A granulate mixture suitable for regenerating a bone contains at least one expandable particle and at least one nondeformable particle. The at least one expandable particle contains a swelling agent. The swelling is enclosed by a biodegradable sheathing or be a biodegradable casing. Three-dimensional callus distraction may be accomplished by introducing the granulated mixture into a bone defect.
1. A granulate mixture suitable for regenerating a bone comprising:
at least one non-deformable particle;
at least one expandable particle, the at least one expandable particle includes a swelling agent; and
a biodegradable sheathing enclosing the swelling agent.
2. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle includes a plurality of non-deformable particles and wherein the at least one expandable particle includes a plurality of expandable particles.
3. The granulate mixture according to claim 1 , wherein a mixing ratio of the expandable particles to the non-deformable particles in the granulate mixture is 1:99 to 99:1, relative to the number of particles.
4. The granulate mixture according to claim 1 , wherein the swelling agent is a hydrogel.
5. The granulate mixture according to claim 1 , wherein the swelling agent expands as the result of absorption of a liquid selected from a group consisting of: a liquid containing biomolecules, cells, and a combination thereof.
6. The granulate mixture according to claim 5 , wherein the liquid is blood.
7. The granulate mixture according to claim 1 , wherein the swelling agent for the at least one expandable particle is composed of a polysaccharide.
8. The granulate mixture according to claim 1 , wherein the swelling agent for the at least one expandable particle is composed of a glucosamine.
9. The granulate mixture according to claim 1 , wherein the at least one expandable particle has a particle size of 0.0001 mm to 10 mm.
10. The granulate mixture according to claim 1 , wherein the at least one expandable particle has a particle size of 0.1 mm to 10 mm.
11. The granulate mixture according to claim 1 , wherein the particles of the plurality of expandable particles are present in at least two different particle sizes.
12. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle contains a bone replacement material.
13. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle contains hydroxyapatite and/or tricalcium phosphate.
14. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle has a particle size of 0.01 mm to 10 mm.
15. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle has a particle size of 0.1 mm to 10 mm.
16. The granulate mixture according to claim 1 , wherein the at least one non-deformable particle is not expandable or is not contractible.
17. The granulate mixture according to claim 1 , wherein the biodegradable sheathing encloses the swelling agent and the at least one non-deformable particle is outside the biodegradable casing when the biodegradable sheathing encloses the swelling agent.
18. The granulate mixture according to claim 17 , wherein the biodegradable sheathing is made of gelatin.
19. A granulate mixture suitable for regenerating a bone, the granulate mixture comprising:
at least one non-deformable particle;
at least one expandable particle, the at least one expandable particle including a swelling agent; and
a biodegradable sheathing enclosing the at least one expandable particle.
20. The granulate mixture according to claim 19 , wherein the granulate mixture including the biodegradable sheathing that is injectable into a bone defect.
21. The granulate mixture according to claim 20 , wherein the non-deformable particle is outside the biodegradable sheathing.
22. The granulate mixture according to claim 19 , wherein the at least one expandable particle increases in volume when in contact with a liquid.
23. The granulate mixture according to claim 22 , wherein the biodegradable sheathing prevents contact between the at least one expandable particle and the liquid until the biodegradable sheathing degrades.