Compounds and their salts specific to the PPAR receptors and the EGF Receptors and their use in the medical field
View Patent ↗The present invention relates to compounds of formula (I), where R 1 and R 2 , which may be identical or different, are selected from the group comprising H, C n H 2n-1 , a linear or branched alkyl group having 1 to 6 carbons, or together form an aromatic or aliphatic ring with 5 or 6 atoms; R 3 is —CO—CH 3 , —NHOH, —OH, or —OR 6 where R 6 is a linear or branched alkyl group having 1 to 6 carbon atoms; R4 is H, linear or branched alkyl group having from 1 to 6 atoms, phenyl, benzyl, —CF 3 or CF 2 CF 3 , vinyl or allyl; R 5 , R 7 , R 8 are hydrogen atoms; or R 3 and R 4 , R 4 and R 5 , or R 7 and R 8 together form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O, and use thereof in the medical field.
1. A compound of the general formula (I)
in which
R 1 and R 2 , which may be identical or different, are selected from the group consisting of H, a linear or branched alkyl group having from 1 to 6 carbon atoms, or together form an aliphatic ring with 5 or 6 atoms;
R 5 , R 7 , R 8 are each independently selected from hydrogen atoms, or —NR 1 R 2 ;
R 3 and R 4 together form an aliphatic ring with 1 to 2 heteroatoms selected independently from N or O;
or a salt thereof.
2. The compound of claim 1 , wherein R 1 and R 2 are each independently selected from the group consisting of: —CH 3 , —C 2 H 5 , isopropyl, or propyl.
3. The compound of claim 1 , wherein R 1 and R 2 , are both H.
4. The compound of claim 1 , represented by:
5. The compound of claim 1 , represented by:
6. A pharmaceutical composition comprising a compound of claim 1 , in combination with one or more pharmaceutically acceptable excipients or adjuvants.
7. A method of treating colon tumours in a human or animal in need thereof, comprising administering to the human or animal a compound according to claim 1 .
8. A method of treating Crohn's disease or ulcerative rectocolitis in a human or animal in need thereof, comprising administering to the human or animal a compound according to claim 1 .
9. A method of treating Crohn's disease, ulcerative rectocolitis or colon cancer in a human or animal in need thereof, comprising administering to the human or animal a compound selected from the group consisting of:
1,2,3,4-tetrahydro-6-hydroxyquinoline-5-carboxylic acid;
6-methoxyquinoline-5-carboxylic acid;
6-methoxy-1,2,3,4-tetrahydroquinoline-5-carboxylic acid,
4-diispropylaminosalicylic acid,
and salts thereof.
10. A method of treating Crohn's disease or ulcerative rectocolitis in a human or animal in need thereof, comprising administering to the human or animal a compound represented by: