IP Library › Granted Patent US 9,119,825
Granted Patent B2
US 9,119,825 · App. 13/401,459 · Granted Sep 1, 2015

PKC-activating compounds for the treatment of neurodegenerative diseases

Inventors: Thomas J. Nelson (Morgantown, WV); Daniel L. Alkon (Bethesda, MD)
Assignee: Blanchette Rockefeller Neurosciences Institute
A61K31/201A61K31/045A61K31/23A61K31/231A61K31/335
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Quick Facts
Patent No.
US 9,119,825
App. No.
13/401,459
Granted
Sep 1, 2015
Kind
B2
Abstract

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

Claims (4)

1. A method of treating at least one neurodegenerative disease and/or mood disorder comprising administering to a subject in need thereof an effective amount of at least one compound chosen from a cis-polyunsaturated fatty acid ester in which at least one of the double bonds is replaced by a cyclopropyl group,

wherein the at least one neurodegenerative disease and/or mood disorder is chosen from Alzheimer's disease, stroke, and depression.

2. The method of claim 1 , wherein the neurodegenerative disease is Alzheimer's disease.

3. The method of claim 1 , wherein the mood disorder is depression.

Assignments (1)
CHANGE OF NAME Recorded Oct 12, 2016
From: BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE, INC.
To: COGNITIVE RESEARCH ENTERPRISES, INC.
Reel/Frame 039994/0260 →
Continuity (3)
Continuation 12510681 · Jul 28, 2009
Provisional Application 61084172 · Jul 28, 2008
Related Publication 20120149768A1 · Jun 14, 2012