Microdialysis probe and method for the production thereof
View Patent ↗A microdialysis probe including a probe body, a supply line and a discharge line for a perfusion solution and a dialysis membrane, wherein a probe needle for introduction into a tissue is provided by a generally elongate frame. The frame has at least one recess at least partially open for receiving at least a portion of the supply and discharge lines. The invention encompasses a method for making such a probe, wherein the method includes arranging a dialysis membrane on a shaping device, shaping the dialysis membrane in a selected shape, applying an adhesive agent to the dialysis membrane to keep the membrane in the selected shape, and separating the dialysis membrane and the shaping devices after the adhesive agent has been applied.
1. A method for making a microdialysis probe, the method comprising:
providing the microdialysis probe comprising a probe body with a probe needle protruding from the probe body in a distal direction for introduction into a tissue;
forming by a dialysis membrane a supply line and a discharge line for a perfusion solution; and
forming the probe needle is substantially by an elongate frame having a longitudinally extending slit formed therein that extends from a proximate end of the needle to a point proximate a distal end of the needle and divides the frame into two branches, such that the supply and discharge lines are received between the two branches, the frame comprises an end remote from the probe body, and the end is disposed distally relative to a distal-most portion of the dialysis membrane.
2. The method as claimed in claim 1 , further comprising merging the supply and discharge lines into one another at a reverse turn crossing the slit.
3. The method as claimed in claim 1 , further comprising providing the frame as one piece.
4. The method as claimed in claim 1 , further comprising providing the frame as an at least partly flexible frame.
5. The method as claimed in claim 1 , wherein the frame comprises an end remote from the probe body, and said method comprises providing the end as a sharp, pointed tip for introduction into the tissue.
6. The method as claimed in claim 1 , further comprising arranging a hollow fiber in the slit in such a way that it turns at a reverse turn area such that two lengths of hollow fiber lie approximately next to one another.
7. The method as claimed in claim 5 , further comprising providing the frame as part of the probe body, wherein the slit is one of inside or adjacent to the probe body.
8. The method as claimed in claim 7 , further comprising providing the frame as a plastic and/or metal.
9. The method as claimed in claim 6 , further comprising securing the hollow fiber of the dialysis membrane such that the hollow fiber is secured on the frame in the reverse turn area.
10. The method as claimed in claim 9 , further comprising providing the hollow fiber in a manner such that the hollow fiber of the dialysis membrane is free between the reverse turn area and the probe body.