IP Library Granted Patent US 8,413,817
Granted Patent B2
US 8,413,817 · App. 13/402,948 · Granted Apr 9, 2013

Non-blocking filtration system

Inventor: Sarfaraz Khan Niazi (Deerfield, IL)
Assignee: Therapeutic Proteins International, LLC
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Quick Facts
Patent No.
US 8,413,817
App. No.
13/402,948
Granted
Apr 9, 2013
Kind
B2
Abstract

A non-blocking filtration system wherein the suspension filtered continuously scrubs the filter, keeping it free of deposits of solid deposits while the filtrate is removed in a variety of biological and chemical applications, substantially reducing the cost of unit operations.

Claims (22)

1. A filtration system to remove a filtrate from a suspension comprising:

a. a circular porous disc with two sides and an inner volume, a plurality of pores ranging from 1 micron to 100 microns and a filtrate port on each side of the disc;

b. a source of vacuum connected to each filtrate port;

c. a turbine propeller assembly equal in diameter to the diameter of the disc and positioned at a distance between 0.1 cm to 1 cm away from the each side of the disc, a means of rotating the turbine propeller and a means of controlling the speed of rotation of the turbine propellers;

d. a housing to hold the disc and the turbine propellers in place.

2. The filtration system according to claim 1 , wherein the disc is covered by a filter membrane with a plurality of pores ranging from 0.1 μm to 5 μm.

3. The filtration system according to claim 1 , wherein the disc is made of polymer, ceramic or metal.

4. The filtration system according to claim 3 , wherein the ceramic material is aluminum oxide.

5. The filtration system according to claim 2 , wherein the filter membrane is made of cellulose, polyethylene or nylon.

6. The filtration system according to claim 1 , wherein the turbine propellers are capable of drawing a suspension and blowing it at a high velocity in the surface of the disc.

7. The filtration system according to claim 1 , wherein the turbine propeller assembly is made of a polymer or metal.

8. The filtration as system according to claim 1 , wherein the means of rotating the turbine propeller comprise a rotating cable connected to the propeller through gears, a gas driven motor or an electric motor.

9. The filtration system according to claim 1 , wherein the turbine propeller is capable of rotating continuously from 100 rpm to 1000 rpm.

10. The filtration system according to claim 1 , wherein the speed of the turbine propeller is automatically adjusted directly in proportion to the intensity of vacuum required for withdrawing the filtrate.

11. The filtration system according to claim 1 , wherein the vacuum source is a peristaltic pump.

12. The filtration system according to claim 1 , wherein the suspension comprises a nutrient media and a biological culture.

13. The filtration system according to claim 1 , wherein the filtration system is disposed completely inside a disposable bioreactor.

14. The filtration system according to claim 1 , wherein the filtration system is disposable.

15. The filtration system according to claim 1 , wherein it is used as a perfusion filter in the manufacturing of recombinant drugs using cell culture.

16. The filtration system according to claim 1 , wherein it is used as a perfusion filter in the clearing of biological fluids of contaminants in clinical use.

17. The filtration system according to claim 1 , wherein it is used to sterilize contaminated liquids in various process industries.

18. The filtration system according to claim 1 , wherein the filtrate removed is the desired product.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 2, 2017
From: ADELLO BIOLOGICS, LLC
To: NIAZI, SARFARAZ K.
Reel/Frame 041161/0542 →
CHANGE OF NAME Recorded Feb 2, 2017
From: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
To: ADELLO BIOLOGICS, LLC
Reel/Frame 041605/0782 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 27, 2012
From: NIAZI, SARFARAZ K.
To: THERAPEUTIC PROTEINS INTERNATIONAL, LLC
Reel/Frame 028853/0385 →
Continuity (2)
Continuation 13149856 · May 31, 2011
Related Publication 20120152862A1 · Jun 21, 2012