Temperature-adjusted analyte determination for biosensor systems

1. A method for determining an analyte concentration in a sample of a biological fluid, comprising:

determining a sample temperature of the sample;

generating an output signal in response to a redox reaction of an analyte in the sample;

adjusting a correlation between output signals at a reference temperature and analyte concentrations, to a temperature-adjusted correlation between output signals at the sample temperature and analyte concentrations, in response to the sample temperature; and

after adjusting the correlation, determining the analyte concentration in the sample from the temperature-adjusted correlation and the output signals at the sample temperature.

2. The method of claim 1 , further comprising adjusting the correlation in response to a normalized temperature function of slope and a normalized temperature function of intercept.

3. The method of claim 1 , where the temperature-adjusted correlation between analyte concentrations and output signals is represented as follows:

A

R

=

OS

T

-

Int

T

S

T

,

where A R is the analyte concentration at the reference temperature, OS T is the output signal at the sample temperature, Int T is an intercept of the correlation at the reference temperature adjusted by a normalized temperature function for intercept, and S T is a slope of the correlation at the reference temperature adjusted by a normalized temperature function for slope.

4. The method of claim 3 , where the normalized temperature function for slope comprises a regression analysis of normalized slopes.

5. The method of claim 4 , where the normalized temperature function for slope, f(T), is represented as follows:

f ( T )= a 2 T 2 +a 1 T+a 0 ,

where T is the sample temperature and a 2 , a 1 , and a 0 are coefficients of a regression analysis representing the normalized slopes.

6. The method of claim 3 , where the normalized temperature function for intercept comprises a regression analysis of normalized intercepts.

7. The method of claim 6 , where the normalized temperature function for intercept, g(T) is represented as follows:

g ( T )= b 2 T 2 +b 1 T+b 0 ,

where T is the sample temperature and b 2 , b 1 , and b 0 are coefficients of a regression analysis representing the normalized intercepts.

8. The method of claim 1 , further comprising generating the output signal in response to an electrochemical process.

9. The method of claim 1 , where the output signal comprises light.

10. The method of claim 1 , where the output signal comprises an electrical signal.

11. The method of claim 1 , further comprising generating the output signal in response to pulsed input signals.

12. The method of claim 1 , where the analyte comprises glucose and the biological fluid comprises whole blood.

13. The method of claim 1 , where determining a sample temperature of the sample comprises measuring the sample temperature, calculating the sample temperature from the output signal, or measuring an ambient temperature and assuming the sample temperature to be the same or similar to the ambient temperature.

14. A biosensor for determining an analyte concentration in a biological fluid, comprising:

a measuring device having a processor connected to a sensor interface and a temperature sensor; and

a sensor strip having a reservoir for a liquid sample, and a sample interface in communication with the sensor interface;

where the processor adjusts a correlation between output signals at a reference temperature and analyte concentrations, to a temperature-adjusted correlation between output signals at a sample temperature and analyte concentrations, in response to a sample temperature from the temperature sensor; and

where, after the processor adjusts the correlation, the processor determines an analyte concentration in a sample of a biological fluid in the reservoir of the sensor strip from the temperature-adjusted correlation and an output signal from the sample.

15. The biosensor of claim 14 , where the processor adjusts the correlation in response to a normalized temperature function of slope and a normalized temperature function of intercept.

16. The biosensor of claim 14 where the temperature-adjusted correlation is represented as follows:

G

R

=

i

T

-

(

Int

R

*

g

⁡

(

T

)

)

(

S

R

*

f

⁡

(

T

)

)

,

where G R is an analyte concentration at the reference temperature, i T is the output signal at a sample temperature, Int R is an intercept of the correlation for the reference temperature, g(T) is a normalized temperature function for intercept, S R is a slope of the correlation for the reference temperature, and f(T) is a normalized temperature function for slope.

17. The biosensor of claim 16 , where the normalized temperature function for slope, f(T), is represented as follows:

f ( T )= a 2 T 2 +a 1 T+a 0 ,

where T is the sample temperature and a 2 , a 1 , and a 0 are coefficients of a regression analysis representing normalized slopes.

18. The biosensor of claim 16 , where the normalized temperature function for intercept, g(T) is represented as follows:

g ( T )= b 2 T 2 +b 1 T+b 0 ,

where T is the sample temperature and b 2 , b 1 , and b 0 are coefficients of a regression analysis representing normalized intercepts.

19. The biosensor of claim 14 , where the output signal comprises light.

20. The biosensor of claim 14 , where the output signal comprises an electrical signal.

21. The biosensor of claim 14 , where the output signal is responsive to pulsed input signals.

22. The biosensor of claim 14 , where the analyte comprises glucose and the biological fluid comprises whole blood.

23. The biosensor of claim 14 , where the sample temperature is determined by measuring the sample temperature, by calculating the sample temperature from the output signal, or by measuring an ambient temperature and assuming the sample temperature to be the same or similar to the ambient temperature.