IP Library Granted Patent US 8,911,467
Granted Patent B2
US 8,911,467 · App. 13/413,275 · Granted Dec 16, 2014

Methods and systems for performing submucosal medical procedures

Inventors: Vladimir Mitelberg (Austin, TX); Donald K. Jones (Dripping Springs, TX); David Y. Yuan (Austin, TX); Brett E. Naglreiter (Austin, TX); J. Landon Gilkey (Austin, TX); Christopher J. Gostout (Rochester, MN); Pankaj J. Pasricha (Houston, TX)
Assignees: Mayo Foundation for Medical Education and Research; The Board of Regents of the University of Texas System; Apollo Endosurgery, Inc.
A61B17/3478A61B2018/1407A61B17/22031A61B10/0283A61B17/32056A61B2018/00291A61B2017/00539A61B2017/320048A61B18/1477A61B2018/1425A61B2017/2937A61B18/22A61B17/320783A61B18/1492A61B2017/00269
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Quick Facts
Patent No.
US 8,911,467
App. No.
13/413,275
Granted
Dec 16, 2014
Kind
B2
Abstract

Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.

Claims (11)

1. A method of forming a submucosal tunnel comprising the steps of:

elevating a mucosal layer at a target site by injecting a fluid into a submucosal layer beneath the mucosal layer using a needle assembly to form an elevated bleb;

inserting a submucosal tunneling instrument through a natural orifice into the digestive tract of a mammal, said submucosal tunneling instrument comprising an elongate tubular member having proximal and distal ends and a lumen extending therethrough and an expandable member having proximal and distal ends wherein the proximal end of said expandable member is attached to the distal end of said tubular member and the distal end of said expandable member is everted and positioned within the lumen of said tubular member;

inserting said submucosal tunneling instrument into the elevated bleb beneath said mucosal layer; and

operating said submucosal tunneling instrument to create an elongate tunnel in the submucosal layer, said operating includes expanding said expandable member substantially greater in length than in diameter to form a narrow space in the submucosal layer.

2. A method of forming a submucosal tunnel according to claim 1 , wherein once said submucosal tunneling instrument is inserted into the elevated bleb, said elongate tubular member is maintained in a longitudinal position while said expandable member is expanded to create the entire submucosal tunnel.

3. A method of forming a submucosal tunnel according to claim 1 , wherein said operating said submucosal tunneling instrument to create the elongate tunnel in the submucosal layer consists essentially of expanding said expandable member.

4. A method of forming a submucosal tunnel according to claim 1 , wherein said tunneling instrument has a longitudinal axis, and the elongate tunnel extends coaxial with the longitudinal axis.

5. A method of forming a submucosal tunnel according to claim 1 , further comprising:

providing an endoscope having an instrument channel,

wherein said submucosal tunneling instrument is inserted through the natural orifice while being positioned within said instrument channel of said endoscope.

Assignments (16)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 27, 2023
From: APOLLO ENDOSURGERY US, INC.
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 066128/0655 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 27, 2023
From: APOLLO ENDOSURGERY, INC.
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 066128/0812 →
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 5, 2023
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; LPATH THERAPEUTICS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 063264/0046 →
RELEASE OF SECURITY INTEREST Recorded Dec 30, 2021
From: SLR INVESTMENT CORP. (F/K/A SOLAR CAPITAL LTD.)
To: APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; APOLLO ENDOSURGERY, INC.; LPATH THERAPEUTICS INC.
Reel/Frame 058599/0297 →
SECURITY INTEREST Recorded Dec 23, 2021
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC. (F/K/A LPATH, INC.)
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 058980/0199 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 15, 2019
From: APOLLO ENDOSURGERY US, INC.
To: SOLAR CAPITAL LTD., AS COLLATERAL AGENT
Reel/Frame 048885/0687 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY US, INC. (F/K/A APOLLO ENDOSURGERY, INC.)
Reel/Frame 048622/0328 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY US, INC. (F/K/A APOLLO ENDOSURGERY, INC.)
Reel/Frame 048622/0343 →
CHANGE OF NAME Recorded Mar 27, 2017
From: APOLLO ENDOSURGERY, INC.
To: APOLLO ENDOSURGERY US, INC.
Reel/Frame 042106/0912 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY US, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0821 →
TERMINATION OF PATENT SECURITY INTEREST (RECORDED ON 12/3/13 AT REEL/FRAME 031756/0729 AND ON 1/2/14 AT REEL/FRAME 031910/0460) Recorded Mar 2, 2015
From: OXFORD FINANCE LLC, AS AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 035120/0740 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Mar 2, 2015
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 035120/0843 →
SECURITY AGREEMENT Recorded Dec 3, 2013
From: APOLLO ENDOSURGERY, INC.
To: OXFORD FINANCE LLC, AS AGENT
Reel/Frame 031756/0729 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2013
From: MITELBERG, VLADIMIR; JONES, DONALD K.; YUAN, DAVID Y.; NAGLREITER, BRETT E.; GILKEY, J. LANDON
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 031660/0077 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2013
From: PASRICHA, PANKAJ J.
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 031660/0597 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2013
From: GOSTOUT, CHRISTOPHER J.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 031660/0375 →
Continuity (2)
Division 11775996 · Jul 11, 2007
Related Publication 20120226302A1 · Sep 6, 2012