Resorbable phenolic polymers
View Patent ↗The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
1. A diphenol having structure
wherein m is 0, 1, or 2; n is 0 to 4, and Y is selected from the group consisting of
where q is 0 to 4, p is 1 to 5000, and R′ is selected from the group consisting of H, C.
2. A polymer comprising monomer units having formula
wherein m is 0, 1, or 2; n is 0 to 4, and Y is selected from the group consisting of
where q is 0 to 4, p is 1 to 5000, and R′ is selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C8-C14 alkylaryl, benzyl, and substituted benzyl; and
A is selected from the group consisting of —CO—, —C(═NH)—, and —CO—X—CO—, where X is selected from the group consisting of C 1 -C 18 alkylene, C 1 -C 18 alkenylene, divalent C 6 -C 10 arylene, divalent C 7 -C 18 alkylaryl, CH 2 OCH 2 , CH 2 —O—(CH 2 CH 2 O) s CH 2 , (CH 2 ) r CO 2 (CH 2 CH 2 CH 2 O) s CO(CH 2 ) r , and (CH 2 ) r CO 2 (CH 2 CH 2 O) s CO(CH 2 ) r , where r is 2 to 4 and s is 1 to 5000.
3. The polymer according to claim 2 , wherein the polymer consists essentially of monomer units having formula
where m, n, A and Y are as defined in claim 2 .