Uninterrupted flow pump apparatus and method
View Patent ↗This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
1. A method for providing substantially stable flow of a biological fluid comprising:
introducing said biological fluid into a sealed flexible chamber contained within an outer chamber that is adapted to provide a space containing a pressure sensitive medium around said sealed flexible chamber, the sealed flexible chamber comprising a fluid path between said sealed flexible chamber and the exterior of said outer chamber;
changing the pressure in a uniform and controlled manner within said space around said sealed flexible chamber, wherein said change in pressure is operable to send fluid from said sealed flexible chamber to a receiving container that is in fluid communication with said sealed flexible chamber with uninterrupted flow, and is operable to send fluid from said receiving container to said sealed flexible chamber with uninterrupted flow.
2. The method of claim 1 , wherein said biological fluid is pressure sensitive or flow sensitive.
3. The method of claim 1 , wherein said biological fluid comprises whole blood or blood components.
4. The method of claim 1 , wherein said biological fluid comprises a drug.
5. The method of claim 1 , wherein the contents of said sealed flexible chamber are sterile.
6. The method of claim 1 , wherein said sealed flexible chamber contains buffy coat.
7. The method of claim 1 , wherein said sealed flexible chamber comprises more than one fluid path between said sealed flexible chamber and said exterior of said outer chamber.
8. The method of claim 1 , wherein said fluid path between said sealed flexible chamber and said exterior of said outer chamber comprises at least one valve capable of controlling fluid flow through said fluid path.
9. The method of claim 1 further comprising monitoring one or more properties of fluid displaced into or out of said sealed flexible chamber using a load cell.
10. The method of claim 1 further comprising continuously increasing or decreasing pressure within said space around said sealed flexible chamber using a pressure reservoir.
11. A method for providing substantially stable flow of a biological fluid comprising:
introducing said biological fluid into a sealed flexible chamber contained within an outer chamber that provides a space containing a pressure sensitive medium around said sealed flexible chamber, said sealed flexible chamber comprising a fluid path between said sealed flexible chamber and an exterior of said outer chamber; and,
increasing or decreasing the pressure within said space around said sealed flexible chamber in a uniform and controlled manner using a pressure reservoir and a pressure valve, wherein said pressure reservoir is operable to send fluid from said sealed flexible chamber to a receiving container that is in fluid communication with said sealed flexible chamber with uninterrupted flow, and is operable to send fluid from said receiving container to said sealed flexible chamber with uninterrupted flow.
12. The method of claim 11 , wherein said fluid is pressure sensitive or flow sensitive.
13. The method of claim 11 , wherein said biological fluid comprises whole blood or blood components.
14. The method of claim 13 , wherein said blood components comprise white blood cells, red blood cells or plasma.
15. The method of claim 11 , wherein said biological fluid comprises a drug.
16. The method of claim 15 , wherein said drug is selected from the group consisting of insulin, interferon and erythropoietin.
17. The method of claim 11 , further comprising monitoring said increase or decrease of pressure within said space around said sealed flexible chamber.
18. The method of claim 11 , further comprising monitoring the properties of fluid displaced into or out of said sealed flexible chamber.
19. The method of claim 11 , wherein said pressure sensitive medium comprises air.
20. The method of claim 11 , wherein said pressure sensitive medium comprises a fluid.
21. The method of claim 11 , wherein the contents of said sealed flexible chamber are sterile.
22. The method of claim 11 , wherein said receiving container is in fluid communication with said sealed flexible chamber via a photoactivation element.
23. The method of claim 11 , wherein said sealed flexible chamber comprises more than one fluid path between said sealed flexible chamber and said exterior of said outer chamber.
24. The method of claim 11 , wherein said fluid path between said sealed flexible chamber and said exterior of said outer chamber comprises at least one valve capable of controlling fluid flow through said fluid path.
25. The method of claim 24 , further comprising controlling said at least one valve capable of controlling fluid flow through said fluid path.