Treatment for discoid lupus
View Patent ↗Compounds I and II as well as salts and pharmaceutical compositions containing them are useful for treating diseases and/or disorders of the skin, such as cutaneous lupus, for example acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, or discoid lupus erythematosus. In certain embodiments, the compounds are provided in topical compositions.
1. A method of treating cutaneous lupus, comprising topically administering to a subject having cutaneous lupus an effective amount of a compound of formula I and/or II, or a pharmaceutically acceptable salt form thereof
2. The method of claim 1 , wherein the subject has cutaneous lupus lesions, and the compound is applied topically to the cutaneous lupus lesions.
3. The method of claim 2 , wherein the subject has an acute cutaneous lupus erythematosus, a subacute lupus erythematosus, a chronic cutaneous lupus erythematosus, or a drug induced lupus erythematosus.
4. The method of claim 3 , wherein the subject has an acute cutaneous lupus erythematosus or a subacute lupus erythematosus.
5. The method of claim 3 , wherein the subject has a chronic cutaneous lupus disorder.
6. The method of claim 5 , wherein the chronic cutaneous lupus disorder is discoid lupus erythematosus, chilblain lupus erythematosus, lupus erythematosus-lichen planus overlap syndrome, lupus erythematosus panniculitis, tumid lupus erythematosus, or verrucous lupus erythematosus.
7. The method of claim 6 wherein the discoid lupus erythematosus is a childhood discoid lupus erythematosus, generalized discoid lupus erythematosus, or localized discoid lupus erythematosus.
8. The method of claim 2 , wherein the cutaneous lupus comprises a cutaneous lesion associated with drug induced lupus erythematosus.
9. The method of claim 2 , wherein the compound is also administered systemically to the subject to treat the cutaneous lupus.
10. The method of claim 1 , wherein the pharmaceutically acceptable salt form thereof is a salt of compound II.
11. The method of claim 10 , wherein the salt of compound II is selected from the sodium salt, the potassium salt, the calcium salt, the arginine salt and the choline salt.
12. The method of claim 1 , wherein the compound of formula I and/or II, or the pharmaceutically acceptable salt form thereof, is administered either in combination or adjunctively with an anti-inflammatory, an antihistamine, an antibiotic, or an antiviral medication.
13. A method of treating a subject for chronic cutaneous lupus erythematosus, comprising administering to the subject an effective amount of a compound of formula I and/or II, or a pharmaceutically acceptable salt form thereof
14. The method of claim 13 , wherein the subject has an acute cutaneous lupus erythematosus, a subacute lupus erythematosus, or a chronic cutaneous lupus erythematosus.
15. The method of claim 14 , wherein the subject has an acute cutaneous lupus erythematosus, or a subacute lupus erythematosus.
16. The method of claim l 4 , wherein the subject has a chronic cutaneous lupus disorder.
17. The method of claim 16 , wherein the chronic cutaneous lupus disorder is discoid lupus erythematosus, chilblain lupus erythematosus, lupus erythematosus-lichen planus overlap syndrome, lupus erythematosus panniculitis, tumid lupus erythematosus, or verrucous lupus erythematosus.
18. The method of claim 17 , wherein the chronic cutaneous lupus disorder is discoid lupus erythematosus.
19. The method of claim 18 , wherein the subject does not have systemic lupus erythematosus, and does not have anti-DNA antibodies.
20. The method of claim 19 , wherein the subject does not have anti-ds-DNA antibodies.
21. The method of claim 1 , comprising topically administering to the subject the compound of formula I, or a pharmaceutically acceptable salt form thereof.
22. The method of claim 13 , comprising topically administering to the subject the compound of formula I, or a pharmaceutically acceptable salt form thereof.