Intravascular catheter to deliver unfocused energy to nerves surrounding a blood vessel
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
1. A method of inhibiting a nerve surrounding a blood vessel in a patient comprising:
placing an intravascular catheter inside the blood vessel in the patient, the catheter comprising a piezoelectric component; and
energizing the piezoelectric component to deliver unfocused ultrasound energy towards at least a majority portion of a circumference of the blood vessel to thereby reach the nerve surrounding the blood vessel;
wherein the act of energizing is performed to create a heated region having a toroidal configuration.
2. The method of claim 1 , wherein the unfocused ultrasound energy is low intensity ultrasound.
3. The method of claim 1 , wherein the unfocused ultrasound energy has an energy level that is anywhere from 50 mW/cm2 to 1000 mW/cm2.
4. The method of claim 1 , wherein the unfocused ultrasound energy comprises cavitating energy.
5. The method of claim 1 , further comprising delivering a bioactive agent to the nerve surrounding the blood vessel prior to delivering the unfocused ultrasound energy.
6. The method of claim 1 , further comprising determining a degree of heat resulted from the delivery of the unfocused ultrasound energy.
7. The method of claim 1 , further comprising determining a temperature of the nerve surrounding the blood vessel during the delivery of the unfocused ultrasound energy.
8. The method of claim 7 , wherein the temperature is determined using a MRI scanner.
9. The method of claim 8 , wherein the temperature is maintained between 40 and 60 degrees Celsius.
10. The method of claim 1 , wherein the unfocused ultrasound energy is delivered so that a temperature of the nerve is anywhere from 40 to 60 degrees Celsius.
11. The method of claim 1 , further comprising performing an imaging procedure during the delivery of the unfocused ultrasound energy, wherein the imaging procedure is performed on a part of the patient using an ultrasound imaging device positioned external to the patient.
12. The method of claim 1 , wherein the intravascular catheter further comprises a cooling mechanism to protect an interior surface of the blood vessel.
13. The method of claim 1 , wherein the intravascular catheter further comprises a stabilization mechanism for stabilizing a part of the intravascular catheter relative to the blood vessel.
14. The method of claim 1 , wherein the unfocused ultrasound energy inhibits the nerve with vibration and not by heating the nerve.
15. The method of claim 1 , further comprising detecting the unfocused ultrasound energy using a component placed external to the patient.
16. The method of claim 1 , further comprising:
detecting the unfocused ultrasound energy by an external component; and
using the detected ultrasonic energy to facilitate treatment targeting.
17. The method of claim 1 , wherein the unfocused ultrasound energy radiates outward from the intravascular catheter to intersect an interior wall of the blood vessel to thereby create the heated region having the toroidal configuration.
18. The method of claim 1 , further comprising utilizing a device to detect a progress of the delivery of the ultrasound energy.
19. The method of claim 1 , wherein the catheter further comprises a material which facilitates transmission of the unfocused ultrasound energy to a wall of the blood vessel.
20. The method of claim 1 , wherein the blood vessel is a renal artery, and the nerve comprises a renal nerve.
21. The method of claim 1 , further comprising detecting signals from an autonomic nervous system of the patient prior to, and after, the act of energizing.
22. A method to inhibit a renal nerve traveling to a kidney in a patient comprising:
inserting an intravascular catheter into a renal artery of the patient;
delivering energy from the intravascular catheter to the renal nerve around the artery;
utilizing a device to detect a progress of the delivery of the energy to the nerve;
wherein the act of delivering energy is performed to create a heated region having a toroidal configuration.
23. The method of claim 22 , wherein the energy comprises ultrasound.
24. The method of claim 22 , wherein the energy comprises unfocused ultrasound.
25. The method of claim 22 , wherein the energy comprises radiofrequency energy.
26. The method of claim 22 , wherein the energy comprises vibrational energy.
27. The method of claim 22 , wherein the energy comprises cavitational energy.
28. The method of claim 22 , wherein the progress is detected by measuring a temperature with the device.
29. The method of claim 22 , wherein the progress is detected by measuring a tissue response using the device.
30. The method of claim 22 , wherein the energy is delivered to heat the renal nerve to a temperature that is anywhere from 40 to 60 degrees Celsius.
31. The method of claim 30 , further comprising detecting the temperature using the device.