IP Library Granted Patent US 8,858,549
Granted Patent B2
US 8,858,549 · App. 13/420,487 · Granted Oct 14, 2014

Medical instruments and techniques for treating pulmonary disorders

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Quick Facts
Patent No.
US 8,858,549
App. No.
13/420,487
Granted
Oct 14, 2014
Kind
B2
Abstract

Methods and devices for delivering energy to lung tissue, for example to cause lung volume reduction by generating a flow of vapor and introducing the flow of vapor into the lung where the vapor delivers thermal energy sufficient to modify lung tissue.

Claims (32)

1. A method of applying energy to lung tissue in a lung to treat a lung disorder comprising:

generating a flow of vapor using a media, and introducing the flow of vapor into lung wherein the vapor delivers thermal energy sufficient to modify lung tissue; and

controlling a temperature of a heat of vaporization of the vapor by adjusting the media.

2. The method of claim 1 wherein the introducing the flow of vapor includes the vapor undergoing a vapor-to-liquid phase transition thereby delivering thermal energy.

3. The method of claim 1 wherein introducing the flow of vapor includes delivering the heat of vaporization of the vapor to the lung tissue.

4. The method of claim 1 further comprising generating the flow of vapor by at least one of resistive heating means, radiofrequency (Rf) energy means, microwave energy means, photonic energy means, magnetic induction energy means, compression and decompression means, and ultrasonic energy means.

5. The method of claim 1 , further comprising controlling at least one of the pressure of the flow of vapor, the volume of the flow of vapor and the duration of the flow of vapor.

6. The method of claim 1 wherein modifying lung tissue includes at least one of shrinkage, denaturation, damage, ablation, sealing, occlusion, an immune response and remodeling of lung tissue.

7. The method of claim 6 wherein the lung tissue includes at least one of bronchi, bronchioles, alveoli, parenchyma, diseased lung tissue, normal lung tissue, collagenous lung tissue and interalveolar collateral ventilation tissue.

8. The method of claim 1 wherein the flow of vapor is introduced within a targeted airway.

9. The method of claim 8 wherein introducing the flow of vapor includes pressurizing the flow of vapor sufficiently to extend the flow to airway extremities.

10. The method of claim 1 wherein introducing the flow of vapor is performed over an interval timed to substantially prevent conductive heat transfer to body structure external to a targeted airway.

11. The method of claim 1 wherein introducing the flow of vapor includes providing a vapor having a mass average temperature that is lower than about 100° C.

12. The method of claim 11 wherein the mass average temperature is provided by introducing a selected media into the flow of vapor, the selected media consisting of at least one of a gas, a liquid or particulate matter.

13. The method of claim 12 wherein the selected media includes at least one of depressurized CO 2 , N 2 , O 2 , or H 2 O.

14. The method of claim 1 wherein generating the flow of vapor includes generating the vapor or at least one of water, saline and alcohol.

15. The method of claim 1 wherein introducing the flow of vapor includes introducing at least one substance with the vapor.

16. The method of claim 1 including introducing at least one active agent with the vapor.

17. The method of claim 16 wherein the active agent is selected from a group consisting of an anesthetic an antibiotic, a toxin, a sclerosing agent, alcohol, and an enhancing media.

18. The method of claim 1 further comprising the step of imaging the flow of vapor.

19. The method of claim 1 wherein introducing the flow of vapor is preceded by the step of expanding an expansion structure in a proximal portion of a targeted airway for controlling the direction of the flow of vapor.

20. The method of claim 19 wherein the step of expanding the expansion structure includes evacuating air from the airway distal to the expansion structure prior to introducing the flow of vapor.

21. The method of claim 19 further comprising the step of applying negative pressure to the targeted airway after terminating the flow of vapor.

22. The method of claim 21 wherein the step of applying negative pressure is performed for an interval sufficient for tissue cooling.

23. The method of claim 21 wherein the step of applying negative pressure is performed for an interval sufficient for tissue remodeling.

24. The method of claim 1 further comprising coupling electrical energy to the flow of vapor.

25. The method of claim 24 wherein the flow of vapor includes a plasma.

26. The method of claim 1 wherein the flow of vapor is introduced interstitially.

27. A method of applying energy to lung tissue in a lung to treat a lung disorder comprising:

generating a flow of vapor, and introducing a flow of vapor into an airway within the lung;

pressurizing the flow of vapor sufficiently to extend the flow of vapor to targeted airway extremities;

wherein the vapor delivers thermal energy sufficient to modify lung tissue.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Mar 1, 2018
From: OXFORD FINANCE LLC, AS COLLATERAL AGENT
To: AEGEA MEDICAL INC.
Reel/Frame 045482/0001 →
SECURITY INTEREST Recorded Oct 13, 2017
From: AEGEA MEDICAL INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT AND AS A LENDER
Reel/Frame 044261/0696 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2012
From: SHADDUCK, JOHN H.; HOEY, MICHAEL
To: TSUNAMI MEDTECH, LLC
Reel/Frame 027864/0890 →