Process for the Preparation of (-)-(4-Chloro-Phenyl)-(3-Trifluoromethyl-Phenoxy)-Acetic Acid 2-Acetylamino-Ethyl Ester
The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.
1 - 57 . (canceled)
58 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of 99.7% to 99.9%.
59 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.1% to 99.6%.
60 . The compound of claim 58 having a chemical purity of 99.1% to 99.6%.
61 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of greater than 99.9%.
62 . A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.9%.
63 . The compound of claim 62 , wherein the compound is recrystallized.
64 . The compound of claim 63 , wherein the compound is recrystallized from a single solvent.
65 . The compound of claim 63 , wherein the single solvent is diisopropylether.
66 . The compound of claim 61 having a chemical purity of 99.9%.
67 . A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having an enantiomeric excess of 97.5% to 99.5%.
68 . A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having a chemical purity of 97.5% to 99.5%.
69 . The compound of claim 67 having a chemical purity of 97.5% to 99.5%.